Phosphatidylethanolamine binding protein 1

PEBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BD9, 1BEH, 2L7W, 2QYQ
Identifiers
Aliases	PEBP1, HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP, HEL-S-96, Phosphatidylethanolamine binding protein 1
External IDs	OMIM: 604591 MGI: 1344408 HomoloGene: 37637 GeneCards: PEBP1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	118,145,584 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	117,425,690 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; postcentral gyrus; ; left adrenal gland; ; internal globus pallidus; ; superior frontal gyrus; ; Brodmann area 9; ; prefrontal cortex; ; superior vestibular nucleus; ; optic nerve; ; ventral tegmental area;
	Top expressed in
	testicle; ; spermatid; ; adrenal gland; ; mesencephalon; ; proximal tubule; ; spermatocyte; ; neural tube; ; hippocampus proper; ; lens; ; hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; lipid binding; nucleotide binding; protein kinase binding; phosphatidylethanolamine binding; serine-type endopeptidase inhibitor activity; ATP binding; enzyme binding; peptidase inhibitor activity; RNA binding; signaling receptor binding; mitogen-activated protein kinase binding;
Cellular component	cytoplasm; cytosol; nucleus; extracellular exosome; extracellular space; mitochondrion; mitochondrial outer membrane; Golgi apparatus; synaptic vesicle; cell surface; neuronal cell body; myelin sheath; axon terminus; apical part of cell;
Biological process	MAPK cascade; negative regulation of peptidase activity; negative regulation of endopeptidase activity; regulation of neurotransmitter levels; regulation of the force of heart contraction; response to oxidative stress; human ageing; response to heat; response to wounding; response to toxic substance; response to organonitrogen compound; response to activity; hippocampus development; negative regulation of MAPK cascade; positive regulation of cAMP-mediated signaling; response to ethanol; positive regulation of mitotic nuclear division; sperm capacitation; response to corticosterone; response to cAMP; response to calcium ion; positive regulation of acetylcholine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5037
	23980
	ENSG00000089220
	ENSMUSG00000032959
	P30086
	P70296
	NM_002567
	NM_018858
	NP_002558
	NP_061346
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.^[5]^[6]

Interactions[edit]

Phosphatidylethanolamine binding protein 1 has been shown to interact with:

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032959 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Park S, Yeung ML, Beach S, Shields JM, Yeung KC (May 2005). "RKIP downregulates B-Raf kinase activity in melanoma cancer cells". Oncogene. 24 (21): 3535–40. doi:10.1038/sj.onc.1208435. PMID 15782137. S2CID 25932498.
^ "Entrez Gene: PEBP1 phosphatidylethanolamine binding protein 1".
^ ^a ^b ^c Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (May 2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/mcb.20.9.3079-3085.2000. PMC 85596. PMID 10757792.

Further reading[edit]

Schoentgen F, Jollès P (1995). "From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site". FEBS Lett. 369 (1): 22–6. doi:10.1016/0014-5793(95)00376-K. PMID 7641877. S2CID 25555428.
Ojika K, Mitake S, Tohdoh N, Appel SH, Otsuka Y, Katada E, Matsukawa N (2000). "Hippocampal cholinergic neurostimulating peptides (HCNP)". Prog. Neurobiol. 60 (1): 37–83. doi:10.1016/S0301-0082(99)00021-0. PMID 10622376. S2CID 13466181.
Odabaei G, Chatterjee D, Jazirehi AR, Goodglick L, Yeung K, Bonavida B (2004). Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. Advances in Cancer Research. Vol. 91. pp. 169–200. doi:10.1016/S0065-230X(04)91005-6. ISBN 9780120066919. PMID 15327891. {{cite book}}: |journal= ignored (help)
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Tohdoh N, Tojo S, Agui H, Ojika K (1995). "Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein". Brain Res. Mol. Brain Res. 30 (2): 381–4. doi:10.1016/0169-328X(95)00029-R. PMID 7637590.
Seddiqi N, Bollengier F, Alliel PM, Périn JP, Bonnet F, Bucquoy S, Jollès P, Schoentgen F (1994). "Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues". J. Mol. Evol. 39 (6): 655–60. Bibcode:1994JMolE..39..655S. doi:10.1007/BF00160411. PMID 7807553. S2CID 21554565.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hori N, Chae KS, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (1994). "A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein". Gene. 140 (2): 293–4. doi:10.1016/0378-1119(94)90562-2. PMID 8144042.
Moore C, Perry AC, Love S, Hall L (1996). "Sequence analysis and immunolocalisation of phosphatidylethanolamine binding protein (PBP) in human brain tissue". Brain Res. Mol. Brain Res. 37 (1–2): 74–8. doi:10.1016/0169-328X(95)00285-Z. PMID 8738137.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Banfield MJ, Barker JJ, Perry AC, Brady RL (1998). "Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction". Structure. 6 (10): 1245–54. doi:10.1016/S0969-2126(98)00125-7. PMID 9782050.
Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W (1999). "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP" (PDF). Nature. 401 (6749): 173–7. Bibcode:1999Natur.401..173Y. doi:10.1038/43686. PMID 10490027. S2CID 4379551.
Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W (2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC 85596. PMID 10757792.
Hengst U, Albrecht H, Hess D, Monard D (2001). "The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors". J. Biol. Chem. 276 (1): 535–40. doi:10.1074/jbc.M002524200. PMID 11034991.
Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904.
Maki M, Matsukawa N, Yuasa H, Otsuka Y, Yamamoto T, Akatsu H, Okamoto T, Ueda R, Ojika K (2002). "Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease". J. Neuropathol. Exp. Neurol. 61 (2): 176–85. doi:10.1093/jnen/61.2.176. PMID 11853019.
Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.