Phosphoserine phosphatase
From Wikipedia the free encyclopedia
| phosphoserine phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.3 | ||||||||
| CAS no. | 9025-73-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme phosphoserine phosphatase (EC 3.1.3.3) catalyzes the reaction
- O-phospho-L(or D)-serine + H2O L(or D)-serine + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is O-phosphoserine phosphohydrolase. This enzyme participates in glycine, serine and threonine metabolism.
Structural studies[edit]
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1F5S, 1J97, 1L7M, 1L7N, 1L7O, 1L7P, 1L8L, 1L8O, 1NNL, 2J6Y, 2J6Z, and 2J70.
References[edit]
- Borkenhagen LF, Kennedy EP (1959). "The enzymatic exchange of L-serine with 'O-phospho-L-serine catalyzed by a specific phosphatase". J. Biol. Chem. 234 (4): 849–53. PMID 13654276.
- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 73-78.
- Neuhaus FC, Byrne WL (1959). "Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase". J. Biol. Chem. 234 (1): 113–121. PMID 13610904.
