Pol (HIV)

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The Gag-Pol region containing the protease gene flanked by p6pol at the N-terminus and reverse transcriptase at the C-terminus.

Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene.

Products of pol include:

Reverse transcriptase[edit]

Common to all retroviruses, this enzyme transcribes the viral RNA into double-stranded DNA.


This enzyme integrates the DNA produced by reverse transcriptase into the host's genome.


A protease is any enzyme that cuts proteins into segments. HIV's gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific protease used by HIV cleaves these into separate functional units. Protease inhibitor drugs block this step.

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