RpYN06

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BatCoV RpYN06
Virus classification e
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Subgenus: Sarbecovirus
Species:
Strain:
BatCoV RpYN06

Bat coronavirus RpYN06 is a SARS-like betacoronavirus that infects the horseshoe bat Rhinolophus pusillus, it is the second closest known relative of SARS-CoV-2 with a 94.48% sequence identity.[1]

Phylogenetics[edit]

A phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is:[2][3][4]

SARS‑CoV‑2 related coronavirus

Rc-o319, 81% to SARS-COV-2, Rhinolophus cornutus, Iwate, Japan[5]

SL-ZXC21, 88% to SARS-COV-2, Rhinolophus pusillus, Zhoushan, Zhejiang[6]

SL-ZC45, 88% to SARS-COV-2, Rhinolophus pusillus, Zhoushan, Zhejiang[6]

Pangolin SARSr-COV-GX, 89% to SARS-COV-2, Manis javanica, Smuggled from Southeast Asia[7]

Pangolin SARSr-COV-GD, 91% to SARS-COV-2, Manis javanica, Smuggled from Southeast Asia[8]

RshSTT182, 92.6% to SARS-COV-2, Rhinolophus shameli, Steung Treng, Cambodia[4]

RshSTT200, 92.6% to SARS-COV-2, Rhinolophus shameli, Steung Treng, Cambodia[4]

RacCS203, 91.5% to SARS-COV-2, Rhinolophus acuminatus, Chachoengsao, Thailand[3]

RmYN02, 93.3% to SARS-COV-2, Rhinolophus malayanus Mengla, Yunnan[9]

RpYN06, 94.4% to SARS-COV-2, Rhinolophus pusillus, Xishuangbanna, Yunnan[2]

RaTG13, 96.1% to SARS-COV-2, Rhinolophus affinis, Mojiang, Yunnan

SARS-CoV-2

SARS-CoV-1, 79% to SARS-COV-2


References[edit]

  1. ^ Hong Zhou, Jingkai Ji, Xing Chen, Yuhai Bi, Juan Li, Tao Hu, Hao Song, Yanhua Chen, Mingxue Cui, Yanyan Zhang, Alice C. Hughes, Edward C. Holmes, Weifeng Shi (8 March 2021). "Identification of novel bat coronaviruses sheds light on the 2 evolutionary origins of SARS-CoV-2 and related viruses" (PDF). doi:10.1016/j.cell.2021.06.008. Retrieved 13 June 2021.CS1 maint: uses authors parameter (link)
  2. ^ a b Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, et al. (June 2021). "Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses". Cell: S0092867421007091. doi:10.1016/j.cell.2021.06.008. PMID 34147139.
  3. ^ a b Wacharapluesadee S, Tan CW, Maneeorn P, Duengkae P, Zhu F, Joyjinda Y, et al. (February 2021). "Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia". Nature Communications. 12 (1): 972. doi:10.1038/s41467-021-21240-1. PMC 7873279. PMID 33563978.
  4. ^ a b c Hul V, Delaune D, Karlsson EA, Hassanin A, Tey PO, Baidaliuk A, et al. (26 January 2021). "A novel SARS-CoV-2 related coronavirus in bats from Cambodia". bioRxiv. pp. 2021.01.26.428212. doi:10.1101/2021.01.26.428212.
  5. ^ Murakami S, Kitamura T, Suzuki J, Sato R, Aoi T, Fujii M, et al. (December 2020). "Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan". Emerging Infectious Diseases. 26 (12): 3025–3029. doi:10.3201/eid2612.203386. PMC 7706965. PMID 33219796.
  6. ^ a b Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi:10.1016/j.cub.2020.05.023. PMID 32416074.
  7. ^ Lam TT, Jia N, Zhang YW, Shum MH, Jiang JF, Zhu HC, et al. (July 2020). "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins". Nature. 583 (7815): 282–285. doi:10.1038/s41586-020-2169-0. PMID 32218527.
  8. ^ Liu P, Jiang JZ, Wan XF, Hua Y, Li L, Zhou J, et al. (May 2020). "Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?". PLoS Pathogens. 16 (5): e1008421. doi:10.1371/journal.ppat.1008421. PMID 32407364.
  9. ^ Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi:10.1016/j.cub.2020.05.023. PMID 32416074.