Stephen C. Harrison

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Stephen Harrison
Stephen Harrison in 2014, portrait via the Royal Society
Alma materHarvard University (BA, PhD)
SpouseTomas Kirchhausen
Scientific career
Notable studentsXiaojiang Chen
Websitecrystal.harvard.edu

Stephen C. Harrison is professor of biological chemistry and molecular pharmacology, professor of pediatrics, and director of the Center for Molecular and Cellular Dynamics of Harvard Medical School, head of the Laboratory of Molecular Medicine at Boston Children's Hospital, and investigator of the Howard Hughes Medical Institute.[1]

Education and career

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He received his B.A. in chemistry and physics from Harvard in 1963, and was then a Henry fellow at the MRC Laboratory of Molecular Biology at Cambridge. In 1967, he received his Ph.D. in biophysics from Harvard, was a research fellow there as well as a junior fellow in the Society of Fellows, and joined the Harvard faculty in 1971.

Research

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His wide-ranging studies of protein structure have contributed insights to viral architecture, DNA–protein recognition, and cellular signaling.

Harrison has made important contributions to structural biology, most notably by determining and analyzing the structures of viruses and viral proteins, by crystallographic analysis of protein–DNA complexes,[2][3] and by structural studies of protein-kinase switching mechanisms.[4] The initiator of high-resolution virus crystallography, he has moved from his early work on tomato bushy stunt virus[5] (1978) to the study of more complex human pathogens, including the capsid of human papillomavirus,[6] the envelope of dengue virus,[7] and several components of HIV.[8] He has also turned some of his research attention to even more complex assemblies, such as clathrin-coated vesicles.[9] He led the Structural Biology team at the Center for HIV/AIDS Vaccine Immunology (CHAVI) when it received National Institute of Allergy and Infectious Diseases (NIAID) funding [10] of around $300 million to address key immunological roadblocks to HIV vaccine development and to design, develop and test novel HIV vaccine candidates.

Society memberships

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He is a member of American Academy of Arts and Sciences,[11] National Academy of Sciences,[12] American Philosophical Society,[13] European Molecular Biology Organization, American Crystallographic Association and American Association for the Advancement of Science.

Awards

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Personal life

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Harrison has been married to Tomas Kirchhausen, who is currently a Professor at Harvard Medical School,[18] since 2013.[19][20] They first met in 1978 at a small dinner hosted by Ada Yonath. In the fall of 1979, Tom moved to Cambridge, MA, to work with Harrison, and the two have been in a relationship ever since.[21]

References

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  1. ^ "Awards - Stephen C. Harrison wins Bristol-Myers Squibb infectious diseases r". Newsrx.com. 2005-08-22. Retrieved 2013-01-29.
  2. ^ Anderson JE, Ptashne M, Harrison SC (1987). "Structure of the repressor-operator complex of bacteriophage 434". Nature. 326 (6116): 846–52. Bibcode:1987Natur.326..846A. doi:10.1038/326846a0. PMID 3553959. S2CID 4259005.
  3. ^ Ellenberger TE, Brandl CJ, Struhl K, Harrison SC (December 1992). "The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex". Cell. 71 (7): 1223–37. doi:10.1016/s0092-8674(05)80070-4. PMID 1473154. S2CID 13548424.
  4. ^ Xu W, Harrison SC, Eck MJ (February 1997). "Three-dimensional structure of the tyrosine kinase c-Src". Nature. 385 (6617): 595–602. Bibcode:1997Natur.385..595X. doi:10.1038/385595a0. PMID 9024657. S2CID 4365051.
  5. ^ Harrison SC (June 1969). "Structure of tomato bushy stunt virus. I. The spherically averaged electron density". J. Mol. Biol. 42 (3): 457–83. doi:10.1016/0022-2836(69)90236-8. PMID 5804155.
  6. ^ Modis Y, Trus BL, Harrison SC (September 2002). "Atomic model of the papillomavirus capsid". EMBO J. 21 (18): 4754–62. doi:10.1093/emboj/cdf494. PMC 126290. PMID 12234916.
  7. ^ Modis Y, Ogata S, Clements D, Harrison SC (January 2004). "Structure of the dengue virus envelope protein after membrane fusion". Nature. 427 (6972): 313–9. Bibcode:2004Natur.427..313M. doi:10.1038/nature02165. PMID 14737159. S2CID 4334063.
  8. ^ Huang H, Chopra R, Verdine GL, Harrison SC (November 1998). "Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance". Science. 282 (5394): 1669–75. Bibcode:1998Sci...282.1669H. doi:10.1126/science.282.5394.1669. PMID 9831551.
  9. ^ "Stephen C. Harrison, PhD | Center for HIV/AIDS Vaccine Immunology (CHAVI)". Archived from the original on 2014-05-14. Retrieved 2013-01-12.
  10. ^ "NIAID Funds Center for HIV/AIDS Vaccine Immunology (CHAVI)". Niaid.nih.gov. 2005-07-14. Retrieved 2013-01-29.
  11. ^ "Stephen Coplan Harrison". American Academy of Arts & Sciences. Retrieved 2021-12-08.
  12. ^ "Stephen C. Harrison". www.nasonline.org. Retrieved 2021-12-08.
  13. ^ "APS Member History". search.amphilsoc.org. Retrieved 2021-12-08.
  14. ^ "UCSD, Harvard Biologist Named Recipient of 2007 UCSD/Merck Life Sciences Achievement Award, March 27, 2007".
  15. ^ "Harvard Medical School, William Silen Lifetime Achievement Excellence in Mentoring Awards Recipients".
  16. ^ "Professor Stephen Harrison ForMemRS".
  17. ^ "BrandeisNOW, Lawrence Goodman, Oct. 15, 2018".
  18. ^ "Tom Kirchhausen, PhD - DF/HCC". www.dfhcc.harvard.edu. Retrieved 2021-10-08.
  19. ^ Ramakrishnan, Venki (2018). Gene machine : the race to decipher the secrets of the ribosome (First U.S. ed.). New York. ISBN 978-0-465-09336-6. OCLC 1028187395.{{cite book}}: CS1 maint: location missing publisher (link)
  20. ^ "Love and Medicine". hms.harvard.edu. Retrieved 2023-02-06.
  21. ^ Harrison, Stephen C. (2015-06-02). "Veritas per structuram". Annual Review of Biochemistry. 84 (1): 37–60. doi:10.1146/annurev-biochem-060614-033857. ISSN 0066-4154. PMID 25494302.
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