Transcription termination factor, RNA polymerase I

From Wikipedia the free encyclopedia

TTF1

Identifiers

TTF1, TTF-1, TTF-I, Transcription termination factor, RNA polymerase I, transcription termination factor 1

External IDs

OMIM: 600777 HomoloGene: 135863 GeneCards: TTF1

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q34.13	Start	132,375,548 bp^[1]
Band	9q34.13	End	132,406,851 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

spongy bone

oocyte

secondary oocyte

pylorus

pericardium

cardia

nipple

superior surface of tongue

vena cava

pons

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding chromatin binding
Cellular component	plasma membrane nucleolus nucleoplasm cytosol nucleus
Biological process	DNA-templated transcription, termination negative regulation of DNA replication regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II cell differentiation termination of RNA polymerase I transcription
Sources:Amigo / QuickGO

Species

Human

Mouse


7270


n/a


ENSG00000125482


n/a


Q15361


n/a

RefSeq (mRNA)


NM_001205296 NM_007344


n/a

RefSeq (protein)


NP_001192225 NP_031370


n/a

Location (UCSC)

Chr 9: 132.38 – 132.41 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.^[3]^[4]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125482 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Evers R, Grummt I (Aug 1995). "Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I". Proc Natl Acad Sci U S A. 92 (13): 5827–31. Bibcode:1995PNAS...92.5827E. doi:10.1073/pnas.92.13.5827. PMC 41594. PMID 7597036.
^ "Entrez Gene: TTF1 transcription termination factor, RNA polymerase I".

Further reading[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
Muth V, Nadaud S, Grummt I, Voit R (2001). "Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription". EMBO J. 20 (6): 1353–62. doi:10.1093/emboj/20.6.1353. PMC 145524. PMID 11250901.
Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Takano T, Ito Y, Matsuzuka F, et al. (2007). "Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines". Oncol. Rep. 18 (3): 715–20. doi:10.3892/or.18.3.715. PMID 17671725.

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