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A uniporter is a membrane transport protein that transports a single species of substrate (charged or uncharged) across a cell membrane. It may use either facilitated diffusion and transport along a diffusion gradient or transport against one with an active transport process. Uniporters include both carriers and ion channels, and are referred to as facilitated transporters, suggesting movement down a concentration or electrochemical gradient.
There are several ways in which the opening of uniporter channels may be regulated:
- Voltage – Regulated by the difference in voltage across the membrane
- Stress – Regulated by physical pressure on the transporter (as in the cochlea of the ear)
- Ligand – Regulated by the binding of a ligand to either the intracellular or extracellular side of the cell
Uniporters are found in mitochondria and neurons. The uniporter in the mitochondria is responsible for calcium uptake. The calcium channels are used for cell signaling and triggering apoptosis. The calcium uniporter transports calcium across the inner mitochondrial membrane and is activated by calcium rises above a certain concentration. Voltage-gated potassium channels are also uniporters that can be found in neurons and are essential for action potentials. This channel is activated by a voltage gradient created by sodium-potassium pumps. When the membrane reaches a certain voltage, the channels open which depolarizes the membrane which leads to the action potential being sent down the membrane.
- Cammack, Richard; Atwood, Teresa; Campbell, Peter; Parish, Howard; Smith, Anthony; Vella, Frank; Stirling, John (2006). "uniport". Oxford Dictionary of Biochemistry and Molecular Biology. Oxford University Press. doi:10.1093/acref/9780198529170.001.0001/acref-9780198529170-e-20301. Retrieved 3 June 2020.
- Wolfersberger, MG (November 1994). "Uniporters, Symporters and Antiporters". J Exp Biol. 196: 5–6. PMID 7823043.
- Hoppe, U. (2010). "Mitochondrial Calcium Channels". FEBS Letters: 1975–1981.
- OpenStax College (2013). Chapter 12.4 The Action Potential. OpenStax College. pp. 523–531. ISBN 1938168135.
- Alberts, Bruce et al. — Essential Cell Biology, 1st edition. Garland Publishing, New York: 1998.