The seat, based largely on the market town of Clitheroe, had previously been safely Conservative but at the time Margaret Thatcher's controversial "Poll Tax" policy was used by opposition parties against the Conservative candidate. The tax was abolished soon afterwards by Thatcher's successor John Major, who had succeeded Thatcher on her resignation in November 1990.
The then-young Liberal Democrats maintained the record of their parent parties at often scoring by-election "scalps" by winning apparently-safe seats, although rarely holding them at subsequent general elections. Indeed, despite their victory at Ribble Valley, the Lib Dems lost the seat a little over a year later at the 1992 general election to the Conservative Nigel Evans who held the seat until the 2024 General Election.