| Date | Sport | Venue/Event | Status | Winner/s |
| 1 | Endurance racing |  2021 6 Hours of Spa-Francorchamps (WEC #1) | International | |
| 1 | Horse racing |  2021 Kentucky Derby (Triple Crown #1) | Domestic | |
| 1 | Volleyball |  2020–21 CEV Champions League Final | Continental |  ZAKSA Kędzierzyn-Koźle |
| 1–2 | Athletics | 2021 World Athletics Relays | International | Poland |
| 1–6 | Diving |  2021 FINA Diving World Cup | International |  Great Britain |
| 2 | Formula racing |  2021 Portuguese Grand Prix (F1 #3) | International | Lewis Hamilton ( Mercedes) |
| 2 | Motorcycle racing |  2021 Spanish motorcycle Grand Prix (MotoGP #4) | International | |
| 3 | Futsal |  2021 UEFA Futsal Champions League Final | Continental | Sporting CP |
| 3–9 | Futsal |  2021 CONCACAF Futsal Championship | Continental |  Costa Rica |
| 3–9 | Multi-sport |  2021 World Combat Games | International | Cancelled |
| 6–9 | Canoe slalom | 2021 European Canoe Slalom Championships | Continental |  Czech Republic |
| 6–22 | Association football |  2021 UEFA European Under-17 Championship | Continental | Cancelled |
| 8 | Formula racing |  2021 Monaco ePrix (FE #7) | International | António Félix da Costa ( DS Techeetah) |
| 8–9 | Formula racing | 2021 Barcelona Formula 3 round (F3 #1) | International | |
| 8–9 | Athletics | 2021 European Throwing Cup | Continental | Poland |
| 8–30 | Road bicycle racing | 2021 Giro d'Italia (Grand Tour #1) | International |  Egan Bernal ( Ineos Grenadiers) |
| 9 | Formula racing | 2021 Spanish Grand Prix (F1 #4) | International | Lewis Hamilton ( Mercedes) |
| 9–14 | Nine-ball pool |  2021 World Cup of Pool | International | Germany (Joshua Filler & Christoph Reintjes) |
| 9–16 | Tennis | 2021 Italian Open | International | |
| 10–23 | Aquatics |  2020 European Aquatics Championships† | Continental |  Russia |
| 13–16 | Orienteering |  2021 European Orienteering Championships | Continental |  Sweden |
| 14–16 | Aesthetic group gymnastics | 2021 European Aesthetic Group Gymnastics Championships | Continental | Russia |
| 15 | Association football |  2021 OFC Champions League Final | Continental | Cancelled |
| 15 | Horse racing | 2021 Preakness Stakes (Triple Crown #2) | Domestic | |
| 15–25 | Association football |  2021 Caribbean Club Championship | Regional |  Cavaly |
| 15–7 July | Ice hockey |  / 2021 Stanley Cup playoffs | Domestic |  Tampa Bay Lightning |
| 16 | Association football | 2021 UEFA Women's Champions League Final | Continental | Barcelona |
| 16 | Athletics | 2021 European Race Walking Team Championships | Continental | Spain |
| 16 | Motorcycle racing |  2021 French motorcycle Grand Prix (MotoGP #5) | International | |
| 16–22 | Futsal |  2021 Copa Libertadores de Futsal | Continental |  San Lorenzo |
| 16–22 | Para swimming | 2020 World Para Swimming European Open Championships† | Continental | Italy |
| 17–23 | Beach soccer | 2021 CONCACAF Beach Soccer Championship | Continental |  El Salvador |
| 17–23 | Curling |  2021 World Mixed Doubles Curling Championship | International | Scotland |
| 19–23 | Karate | 2021 European Karate Championships | Continental |  Turkey |
| 20 | Association football | 2021 UEFA Youth League Final | Continental | Cancelled |
| 20–23 | Rallying | 2021 Rally de Portugal (WRC #4) | International | |
| 20–23 | Golf | 2021 PGA Championship (Grand Slam #2) | International | Phil Mickelson |
| 20–23 | Judo |  2021 African Judo Championships | Continental |  Tunisia |
| 20–29 | Futsal |  2021 Arab Futsal Cup | International |  Morocco |
| 20–12 June | Association football |  2021 FIFA U-20 World Cup | International | Cancelled |
| 21–22 | Formula racing | 2021 Monte Carlo Formula 2 round (F2 #2) | International | |
| 21–6 June | Ice hockey |  2021 IIHF World Championship | International | Canada |
| 22 | Rugby union | 2021 European Rugby Champions Cup Final | Continental | Toulouse |
| 22–25 | Nine-ball pool |  2021 World Pool Masters | International |  Alexander Kazakis |
| 22–5 June | Shooting | 2021 European Shooting Championships | Continental | Russia |
| 22–20 July | Basketball | 2021 NBA playoffs | Domestic |  Milwaukee Bucks |
| 23 | Formula racing | 2021 Monaco Grand Prix (F1 #5)† | International |  Max Verstappen ( Red Bull Racing-Honda) |
| 23–29 | Beach soccer | 2021 Africa Beach Soccer Cup of Nations | Continental | Senegal |
| 23–31 | Amateur boxing |  2021 Asian Amateur Boxing Championships | Continental | Kazakhstan |
| 23–31 | Weightlifting |  2021 Junior World Weightlifting Championships | International | Kazakhstan |
| 25–25 June | Volleyball | 2021 FIVB Volleyball Women's Nations League | International | United States |
| 26 | Association football | 2021 UEFA Europa League Final | Continental | Villarreal |
| 26–27 | Artistic gymnastics | 2021 African Artistic Gymnastics Championships | Continental | |
| 27–29 | Aerobic gymnastics |  2021 Aerobic Gymnastics World Championships | International | Russian Gymnastics Federation |
| 27–29 | Weightlifting |  2021 African Weightlifting Championships | Continental | Tunisia |
| 27–30 | Wrestling | 2021 Pan American Wrestling Championships | Continental |  United States |
| 28 | Association football |  2021 CAF Super Cup | Continental | Al Ahly |
| 28–30 | Basketball | 2021 EuroLeague Final Four | Continental | Anadolu Efes |
| 28–27 June | Volleyball | 2021 FIVB Volleyball Men's Nations League | International |  Brazil |
| 29 | Association football | 2021 UEFA Champions League Final | Continental | Chelsea |
| 29–30 | Athletics | 2021 European Athletics Team Championships (Super League) | Continental | Poland |
| 29–30 | Handball | 2020–21 Women's EHF Champions League (Final Four) | Continental |  Vipers Kristiansand |
| 29–30 | Off-road racing | 2021 Ocean X-Prix (Extreme E #2) | International | Johan Kristoffersson &  Molly Taylor ( Rosberg X Racing) |
| 29–31 | Athletics |  2021 South American Championships in Athletics | Continental | Brazil |
| 29–6 June | Surfing | 2021 ISA World Surfing Games | International | |
| 30 | Motorcycle racing | 2021 Italian motorcycle Grand Prix (MotoGP #6) | International | |
| 30 | Indy car racing | 2021 Indianapolis 500 | International | Hélio Castroneves |
| 30–6 June | Street skateboarding | 2021 Street Skateboarding World Championships | International | |
| 30–13 June | Tennis | 2021 French Open (Grand Slam #2) | International | |
| 31–6 June | Archery | 2021 European Archery Championships | Continental | Russia |
| 31–6 June | Association football | / 2021 UEFA European Under-21 Championship knockout stage | Continental | Germany |
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