Azalanstat

Azalanstat
Clinical data
ATC code	None;
Identifiers
	IUPAC name 4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline;
CAS Number	143393-27-5 ;
PubChem CID	60876;
ChemSpider	54858 ;
UNII	2NL79NI1WS;
KEGG	D03025 ;
ChEMBL	ChEMBL70611 ;
CompTox Dashboard (EPA)	DTXSID401029427 ;
Chemical and physical data
Formula	C22H24ClN3O2S
Molar mass	429.96 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)CC[C@@]2(OC[C@H](O2)CSc3ccc(N)cc3)Cn4ccnc4;
	InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1 ; Key:VYNIUBZKEWJOJP-UNMCSNQZSA-N ;
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Azalanstat (INN,^[1] codenamed RS-21607) is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor.^[2]^[3]

References

^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 36" (PDF). World Health Organization. p. 141. Retrieved 3 January 2017.
^ Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, et al. (July 1993). "Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering". Journal of Medicinal Chemistry. 36 (15): 2235–7. doi:10.1021/jm00067a022. PMID 8340925.
^ Burton PM, Swinney DC, Heller R, Dunlap B, Chiou M, Malonzo E, et al. (August 1995). "Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity". Biochemical Pharmacology. 50 (4): 529–44. doi:10.1016/0006-2952(95)00152-p. PMID 7646560.

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Clinical data

ATC code	None
Identifiers
IUPAC name 4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline
CAS Number	143393-27-5^N
PubChem CID	60876
ChemSpider	54858^Y
UNII	2NL79NI1WS
KEGG	D03025^Y
ChEMBL	ChEMBL70611^Y
CompTox Dashboard (EPA)	DTXSID401029427
Chemical and physical data
Formula	C₂₂H₂₄ClN₃O₂S
Molar mass	429.96 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)CC[C@@]2(OC[C@H](O2)CSc3ccc(N)cc3)Cn4ccnc4
InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1^Y Key:VYNIUBZKEWJOJP-UNMCSNQZSA-N^Y
^NY (what is this?)