Combretastatin B-1
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| Names | |
|---|---|
| Preferred IUPAC name 3-Methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethyl]benzene-1,2-diol | |
| Other names Combretastatin B1 | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
PubChem CID | |
| UNII | |
CompTox Dashboard (EPA) | |
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| Properties | |
| C18H22O6 | |
| Molar mass | 334.368 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Combretastatin B-1 is a combretastatin and a dihydrostilbenoid. It can be found in Combretum afrum, the Eastern Cape South African bushwillow tree[1] or in Combretum kraussii, the forest bushwillow.[2]
It can be produced by selective hydrogenation of combretastatin A-1.[1]
It is a potent inhibitor of microtubule assembly in vitro.[1]
References
[edit]- ^ a b c Pettit, G. R.; Singh, S. B.; Niven, M. L.; Hamel, E.; Schmidt, J. M. (1987). "Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum". Journal of Natural Products. 50 (1): 119–131. doi:10.1021/np50049a016. PMID 3598594.
- ^ Bridget K Brookes, Olga V Doudoukina, Lynn C Katsoulis and Joy H D Veale (1999). "Uteroactive constituents from Combretum kraussii". South African Journal of Chemistry. 52 (4): 127. Archived from the original on 8 August 2014.
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