Nazneen Rahman

From Wikipedia the free encyclopedia

Nazneen Rahman
CBE FMedSci
NationalityBritish
Alma mater
Scientific career
ThesisLocalisation and characterisation of the familial tumour gene, FWT1 (1999)
Doctoral advisorMichael Stratton[1]
Websiteicr.ac.uk/our-research/researchers-and-teams/professor-nazneen-rahman

Sabera Nazneen Rahman CBE FMedSci[2] is a geneticist who specialises in cancer research[3] and is a non-executive director for AstraZeneca. She was previously head of Genetics and Epidemiology at the Institute of Cancer Research.[4][5]

Education

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Rahman qualified in medicine from University of Oxford in 1991, and completed a PhD in Molecular Genetics in 1999 on the Wilms' tumor susceptibility gene FWT1.[6][7] She completed her Certificate of Completion of Specialist Training in Clinical Genetics in 2001.

Career and research

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She was head of Genetics and Epidemiology at the Institute of Cancer Research, based at the Sir Richard Doll Building in Sutton. She specialises in research into the genetic mechanisms that cause cancer, particularly among groups with a predisposition to pediatric cancers or breast cancer.[8] Through her research, Professor Rahman has provided improved screening and treatment options for NHS patients, and also provides advice on rare cancer genetics to clinicians internationally.[9] She blogs about her work at Harvesting the Genome.[10]

Rahman held a clinical role as head of the cancer genetics service at The Royal Marsden and St George's Hospital in south west London.[1]

Rahman resigned from her position following in October 2018 following upholding on independent investigation of a complaint of systematic bullying spanning 15 years from 44 of her current and former staff and students .[11] Rahman also lost a £3.5-million grant from the Wellcome Trust.[12]

In 2017 Rahman was appointed Non-Executive Director and member of the Science Committee at AstraZeneca Plc.[13]

Awards and honours

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Rahman was elected a Fellow of the Academy of Medical Sciences in 2010. Her nomination reads:[2]

Nazneen Rahman is Professor of Human Genetics at the Institute of Cancer Research and Head of the Clinical Genetics Department at the Royal Marsden Hospital. Her research work has been directed towards the mapping, identification and clinical characterisation of human disease genes using genome-wide linkage analysis, positional cloning, candidate gene resequencing, genome-wide association analyses and epigenetic assays. Her primary areas of research are breast cancer susceptibility, childhood cancer susceptibility and human growth disorders. In her relatively short career to date she has already identified and characterised 4 breast cancer predisposition genes and two childhood cancer predisposition genes and two overgrowth genes.

In April 2014, she was named as Britain's third most influential woman in the BBC Woman's Hour power list 2014.[14] In February 2016, she was awarded the Services to Science & Engineering award at the British Muslim Awards.[15]

She was appointed Commander of the Order of the British Empire (CBE) in the 2016 Birthday Honours for services to medical science.[16]

Personal life

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Rahman is also a singer-songwriter, with two albums and one EP released.[17]

See also

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References

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  1. ^ a b "Royal Marsden: Professor Nazneen Rahman". Archived from the original on 2 February 2015.
  2. ^ a b "Professor Nazneen Rahman FMedSci". London: The Academy of Medical Sciences. Archived from the original on 6 May 2014.
  3. ^ Futreal, P. A.; Coin, L; Marshall, M; Down, T; Hubbard, T; Wooster, R; Rahman, N; Stratton, M. R. (2004). "A census of human cancer genes". Nature Reviews Cancer. 4 (3): 177–83. doi:10.1038/nrc1299. PMC 2665285. PMID 14993899.
  4. ^ Burton, P. R.; Clayton, D. G.; Cardon, L. R.; Craddock, N.; Deloukas, P.; Duncanson, A.; Kwiatkowski, D. P.; McCarthy, M. I.; Ouwehand, W. H.; Samani, N. J.; Todd, J. A.; Donnelly, P.; Barrett, J. C.; Burton, P. R.; Davison, D.; Donnelly, P.; Easton, D.; Evans, D.; Leung, H. T.; Marchini, J. L.; Morris, A. P.; Spencer, C. C. A.; Tobin, M. D.; Cardon, L. R.; Clayton, D. G.; Attwood, A. P.; Boorman, J. P.; Cant, B.; Everson, U.; Hussey, J. M. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.
  5. ^ Easton, Douglas F.; Pooley, Karen A.; Dunning, Alison M.; Pharoah, Paul D. P.; Thompson, Deborah; Ballinger, Dennis G.; Struewing, Jeffery P.; Morrison, Jonathan; Field, Helen; Luben, Robert; Wareham, Nicholas; Ahmed, Shahana; Healey, Catherine S.; Bowman, Richard; Meyer, Kerstin B.; Haiman, Christopher A.; Kolonel, Laurence K.; Henderson, Brian E.; Le Marchand, Loic; Brennan, Paul; Sangrajrang, Suleeporn; Gaborieau, Valerie; Odefrey, Fabrice; Shen, Chen-Yang; Wu, Pei-Ei; Wang, Hui-Chun; Eccles, Diana; Evans, D. Gareth; Peto, Julian; Fletcher, Olivia; Johnson, Nichola; Seal, Sheila; Stratton, Michael R.; Rahman, Nazneen; Chenevix-Trench, Georgia; Bojesen, Stig E.; Nordestgaard, Børge G.; Axelsson, Christen K.; Garcia-Closas, Montserrat; Brinton, Louise; Chanock, Stephen; Lissowska, Jolanta; Peplonska, Beata; Nevanlinna, Heli; Fagerholm, Rainer; Eerola, Hannaleena; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Hunter, David J.; Hankinson, Susan E.; Cox, David G.; Hall, Per; Wedren, Sara; Liu, Jianjun; Low, Yen-Ling; Bogdanova, Natalia; Schürmann, Peter; Dörk, Thilo; Tollenaar, Rob A. E. M.; Jacobi, Catharina E.; Devilee, Peter; Klijn, Jan G. M.; Sigurdson, Alice J.; Doody, Michele M.; Alexander, Bruce H.; Zhang, Jinghui; Cox, Angela; Brock, Ian W.; MacPherson, Gordon; Reed, Malcolm W. R.; Couch, Fergus J.; Goode, Ellen L.; Olson, Janet E.; Meijers-Heijboer, Hanne; van den Ouweland, Ans; Uitterlinden, André; Rivadeneira, Fernando; Milne, Roger L.; Ribas, Gloria; Gonzalez-Neira, Anna; Benitez, Javier; Hopper, John L.; McCredie, Margaret; Southey, Melissa; Giles, Graham G.; Schroen, Chris; Justenhoven, Christina; Brauch, Hiltrud; Hamann, Ute; Ko, Yon-Dschun; Spurdle, Amanda B.; Beesley, Jonathan; Chen, Xiaoqing; Mannermaa, Arto; Kosma, Veli-Matti; Kataja, Vesa; Hartikainen, Jaana; Day, Nicholas E.; Cox, David R.; Ponder, Bruce A. J. (June 2007). "Genome-wide association study identifies novel breast cancer susceptibility loci". Nature. 447 (7148): 1087–1093. doi:10.1038/nature05887. ISSN 1476-4687. PMC 2714974.
  6. ^ Rahman, N.; Arbour, L.; Tonin, P.; Renshaw, J.; Pelletier, J.; Baruchel, S.; Pritchard-Jones, K.; Stratton, M. R.; Narod, S. A. (1996). "Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21". Nature Genetics. 13 (4): 461–463. doi:10.1038/ng0896-461. ISSN 1061-4036. PMID 8696342. S2CID 19914321.
  7. ^ Rahman, N; Abidi, F; Ford, D; Arbour, L; Rapley, E; Tonin, P; Barton, D; Batcup, G; Berry, J; Cotter, F; Davison, V; Gerrard, M; Gray, E; Grundy, R; Hanafy, M; King, D; Lewis, I; Ridolfi Luethy, A; Madlensky, L; Mann, J; O'Meara, A; Oakhill, T; Skolnick, M; Strong, L; Stratton, M. R. (1998). "Confirmation of FWT1 as a Wilms' tumour susceptibility gene and phenotypic characteristics of Wilms' tumour attributable to FWT1". Human Genetics. 103 (5): 547–56. doi:10.1007/pl00008708. PMID 9860296. S2CID 7082835.
  8. ^ Yost, Shawn; de Wolf, Bas; Hanks, Sandra; Zachariou, Anna; Marcozzi, Chiara; Clarke, Matthew; de Voer, Richarda M.; Etemad, Banafsheh; Uijttewaal, Esther; Ramsay, Emma; Wylie, Harriet (July 2017). "Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation". Nature Genetics. 49 (7): 1148–1151. doi:10.1038/ng.3883. ISSN 1546-1718. PMC 5493194. PMID 28553959.
  9. ^ "Institute of Cancer Research: Professor Nazneen Rahman". Archived from the original on 25 August 2014.
  10. ^ "Harvesting the genome". Archived from the original on 27 May 2017. Retrieved 11 April 2014.
  11. ^ "Top cancer genetics professor quits job over bullying allegations". The Guardian. 17 July 2018.
  12. ^ Else, Holly (2018). "Top geneticist loses £3.5-million grant in first test of landmark bullying policy". Nature. 560 (7719): 420. doi:10.1038/d41586-018-06009-9. PMID 30131539. S2CID 256769330.
  13. ^ "AstraZeneca appoints Professor Nazneen Rahman to its Board of Directors and Science Committee". www.astrazeneca.com. Retrieved 6 December 2019.
  14. ^ "Woman's Hour Power List 2014 – Game Changers". BBC Radio 4.
  15. ^ "British Muslim Awards 2016". Asian World. 17 February 2016. Archived from the original on 21 April 2016. Retrieved 1 April 2016.
  16. ^ "No. 61608". The London Gazette (Supplement). 11 June 2016. p. B9.
  17. ^ "Rahman's website, NazneenRahman.com".
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