PHF10

PHF10
Identifiers
Aliases	PHF10, BAF45A, XAP135, PHD finger protein 10, SMARCG4
External IDs	OMIM: 613069; MGI: 1919307; HomoloGene: 10112; GeneCards: PHF10; OMA:PHF10 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	169,725,566 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,181,535 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; left ovary; ; right adrenal cortex; ; right ovary; ; left adrenal cortex; ; C1 segment; ; Skeletal muscle tissue of rectus abdominis; ; gastric mucosa; ; right lung; ; body of pancreas;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; calvaria; ; tail of embryo; ; spermatocyte; ; seminiferous tubule; ; abdominal wall; ; vas deferens; ; human fetus; ; ventricular zone; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; histone acetyltransferase activity; histone binding;
Cellular component	nucleus; npBAF complex; histone acetyltransferase complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; nervous system development; histone acetylation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	55274
	72057
	ENSG00000130024
	ENSMUSG00000023883
	Q8WUB8
	Q9D8M7
	NM_133325; NM_018288
	NM_024250; NM_001360983
	NP_060758; NP_579866
	NP_077212; NP_001347912
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene.^[5]^[6]

Function

This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130024 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023883 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aradhya S, Woffendin H, Bonnen P, Heiss NS, Yamagata T, Esposito T, Bardaro T, Poustka A, D'Urso M, Kenwrick S, Nelson DL (January 2002). "Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28". Genomics. 79 (1): 31–40. doi:10.1006/geno.2001.6680. PMID 11827455.
^ ^a ^b "Entrez Gene: PHF10 PHD finger protein 10".

External links

PHF10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130024 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023883 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11827455-5] Aradhya S, Woffendin H, Bonnen P, Heiss NS, Yamagata T, Esposito T, Bardaro T, Poustka A, D'Urso M, Kenwrick S, Nelson DL (January 2002). "Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28". Genomics. 79 (1): 31–40. doi:10.1006/geno.2001.6680. PMID 11827455.

[entrez-6] "Entrez Gene: PHF10 PHD finger protein 10".

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PHF10

Function

References

Further reading

External links

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