Ronald Duman
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Ronald Duman | |
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| Born | Ronald Stanton Duman February 6, 1954 Ebensburg, Pennsylvania, U.S. |
| Died | February 1, 2020 (aged 65) Guilford, Connecticut, U.S. |
| Alma mater | College of William & Mary University of Texas Health Science Center at Houston |
| Occupation | Neuroscientist |
Ronald Stanton Duman (February 6, 1954 – February 1, 2020)[1] was a Professor of Psychiatry and Pharmacology Director, Division of Molecular Psychiatry and Abraham Ribicoff Research Facilities at Yale University.[2]
Education
[edit]Duman graduated from the College of William & Mary (where he played varsity football as a middle linebacker) in 1976. He received his Ph.D. from the University of Texas Health Science Center at Houston (UTHealth) in 1985.
Career
[edit]Ron Duman's research centered around the biological mechanisms behind antidepressants. In his landmark 1995 paper, he discovered that antidepressants increase the gene expression of Brain-Derived Neurotrophic Factor, or (BDNF)[3] in the hippocampus. In a later paper he discovered that the downstream effect of BDNF is to increase neurogenesis or the formation of new neurons in the dentate gyrus of the hippocampus.[4]
The results of this work led him to formulate the hypothesis that depression is caused by a decrease in hippocampal neurogenesis caused by elevated cortisol levels.
Death
[edit]Ronald Duman died on February 1, 2020, at the age of 65 while hiking in Guilford, Connecticut.[5]
Notes
[edit]- ^ "Ronald Stanton Duman, PhD (Obituary)". The Tribune-Democrat. February 6, 2020. Retrieved February 8, 2020.
- ^ Duman's Yale Faculty Website Archived 3 June 2009 at the Wayback Machine
- ^ Pramanick, D.; Forstová, J.; Pivec, L. (1976). "First paper demonstrating the link between antidepressants and BDNF levels". FEBS Letters. 62 (1): 81–84. doi:10.1016/0014-5793(76)80021-x. PMID 2505. S2CID 20044419. Archived from the original on June 22, 2022. Retrieved September 11, 2017.
- ^ Malberg, J. E.; Eisch, A. J.; Nestler, E. J.; Duman, R. S. (2000). "Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus". The Journal of Neuroscience. 20 (24): 9104–9110. doi:10.1523/JNEUROSCI.20-24-09104.2000. PMC 6773038. PMID 11124987.
- ^ Ronald S. Duman, PhD, Pioneering Neuroscientist of Stress, Depression, and Antidepressant Treatment Dies at 65
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