TESK2

TESK2
Identifiers
Aliases	TESK2, testis-specific kinase 2, testis associated actin remodelling kinase 2
External IDs	OMIM: 604746; MGI: 2385204; HomoloGene: 5188; GeneCards: TESK2; OMA:TESK2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,491,163 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,663,153 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; C1 segment; ; secondary oocyte; ; skin of abdomen; ; jejunal mucosa; ; skin of limb; ; skin of leg; ; duodenum; ; skin of arm; ; testicle;
	Top expressed in
	granulocyte; ; spermatid; ; lobe of prostate; ; sciatic nerve; ; utricle; ; seminiferous tubule; ; vestibular membrane of cochlear duct; ; left colon; ; stria vascularis; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; nucleotide binding; protein binding; ATP binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; signal transducer activity;
Cellular component	nucleoplasm; nucleus; cytoplasm; nuclear body;
Biological process	protein phosphorylation; peptidyl-tyrosine phosphorylation; focal adhesion assembly; actin cytoskeleton organization; spermatogenesis; phosphorylation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10420
	230661
	ENSG00000070759
	ENSMUSG00000033985
	Q96S53
	Q8VCT9
	NM_007170; NM_001320800
	NM_146151
	NP_001307729; NP_009101
	NP_666263
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.^[5]^[6]

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070759 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033985 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
^ ^a ^b "Entrez Gene: TESK2 testis-specific kinase 2".

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". The Journal of Biological Chemistry. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (August 2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". The Journal of Biological Chemistry. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070759 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033985 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10512679-5] Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.

[entrez-6] "Entrez Gene: TESK2 testis-specific kinase 2".

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TESK2

Function

References

Further reading

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