FOXP3 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/6/60/FOXP3.png/250px-FOXP3.png) |
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識別號 |
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别名 | FOXP3;, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3 |
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外部ID | OMIM:300292 MGI:1891436 HomoloGene:8516 GeneCards:FOXP3 |
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相關疾病 |
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IPEX症候群[1] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PBB_GE_FOXP3_221333_at_fs.png/250px-PBB_GE_FOXP3_221333_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/PBB_GE_FOXP3_221334_s_at_fs.png/250px-PBB_GE_FOXP3_221334_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • sequence-specific DNA binding • NF-kappaB binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • 血浆蛋白结合 • histone deacetylase binding • DNA结合转录因子活性 • NFAT protein binding • histone acetyltransferase binding • 金屬離子結合 • DNA结合 • protein homodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding
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細胞組分 | • 细胞核 • 胞內 • 細胞質 • 核质 • 大分子复合体
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生物學過程 | • negative regulation of cell population proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription by RNA polymerase II • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • 腫瘤壞死因子產生的負調控 • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T细胞活化 • positive regulation of immature T cell proliferation in thymus • positive regulation of regulatory T cell differentiation • negative regulation of transcription by RNA polymerase II • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • 染色体重建 • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression • anatomical structure morphogenesis • regulation of Wnt signaling pathway • regulation of regulatory T cell differentiation
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr X: 49.25 – 49.27 Mb | Chr X: 7.44 – 7.46 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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FOXP3(Forkhead box protein P3)基因,即叉头框P3基因,也称为scurfin蛋白,位于X染色体,属于FOX蛋白家族,是一种与免疫系统响应有关的转录因子[6]。
参考文献[编辑]
- ^ 與FOXP3相關的疾病;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001. S2CID 13389419. doi:10.1038/83784.
外部链接[编辑]
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| (2.2) 其他的Cys4结构 | |
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| (2.3) Cys2His2 | |
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| (2.4) Cys6 | |
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| (2.5)交替composition | |
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| (3.2)配对框 | |
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| (3.6)TEA结构域 | transcriptional enhancer factor( 1、 2、 3、 4) |
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| | (4) 具有小凹槽触点的β-支架因子 |
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| (4.3) p53样转录因子 | |
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| (4.11) Runt | |
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| | (0) 其他转录因子 |
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| (0.2) HMGI(Y) | |
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| (0.6) Miscellaneous | |
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