60S ribosomal protein L23a

RPL23A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL23A, L23A, MDA20, ribosomal protein L23a
External IDs	OMIM: 602326; MGI: 3040672; HomoloGene: 133569; GeneCards: RPL23A; OMA:RPL23A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,724,359 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,074,410 bp
RNA expression pattern
	Top expressed in
	left ovary; ; Achilles tendon; ; canal of the cervix; ; right ovary; ; right uterine tube; ; ectocervix; ; pituitary gland; ; skin of abdomen; ; body of uterus; ; skin of leg;
	Top expressed in
	ovary; ; epiblast; ; ganglionic eminence; ; thymus; ; ventricular zone; ; uterus; ; embryo; ; adrenal gland; ; lip; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	rRNA binding; structural constituent of ribosome; protein binding; cadherin binding; RNA binding; TORC2 complex binding; large ribosomal subunit rRNA binding;
Cellular component	cytoplasm; cytosol; ribosome; intracellular anatomical structure; nucleolus; cytosolic large ribosomal subunit; extracellular exosome; nucleus; TORC2 complex;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; ribosomal large subunit assembly; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; cell population proliferation; protein biosynthesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6147
	268449
	ENSG00000198242
	ENSMUSG00000058546
	P62750
	P62751
	NM_000984
	NM_207523
	NP_000975
	NP_997406
	Wikidata
View/Edit Human	View/Edit Mouse

Large ribosomal subunit protein uL23 is a protein that in humans is encoded by the RPL23A gene.^[5]^[6]

Function

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 rRNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL23 family. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Clinical significance

L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients.^[7]

Pseudogenes

95 related pseudogenes are known, with symbols RPL23AP1 - RPL23AP97, excluding RPL23AP9 and RPL23AP13.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198242 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058546 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID 9417910.
^ ^a ^b "Entrez Gene: RPL23A ribosomal protein L23a".
^ Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. Bibcode:2014Sci...346..363I. doi:10.1126/science.1259077. PMC 5554397. PMID 25324392.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198242 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058546 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417910-5] Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID 9417910.

[entrez-6] "Entrez Gene: RPL23A ribosomal protein L23a".

[Ito_2014-7] Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. Bibcode:2014Sci...346..363I. doi:10.1126/science.1259077. PMC 5554397. PMID 25324392.

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