Protein-coding gene in the species Homo sapiens
ATP6AP2 Identifiers Aliases ATP6AP2 External IDs OMIM : 300556 ; MGI : 1917745 ; HomoloGene : 38097 ; GeneCards : ATP6AP2 ; OMA :ATP6AP2 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in visceral pleura tibia germinal epithelium parietal pleura epithelium of nasopharynx retinal pigment epithelium mucosa of paranasal sinus orbitofrontal cortex lateral nuclear group of thalamus renal medulla
Top expressed in Epithelium of choroid plexus Paneth cell ciliary body iris retinal pigment epithelium conjunctival fornix substantia nigra medial dorsal nucleus medial geniculate nucleus aortic valve
More reference expression data
BioGPS
Wikidata
The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2 , or the prorenin receptor , is a protein that in humans is encoded by the ATP6AP2 gene .[ 5] [ 6] [ 7]
The renin receptor binds renin and prorenin . Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I .[ 8]
This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules" . J Biol Chem . 273 (18): 10939–47. doi :10.1074/jbc.273.18.10939 PMID 9556572 . ^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis . 7 : 234–9. PMID 11590366 . ^ a b "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2" .^ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin" . J. Clin. Invest . 109 (11): 1417–27. doi :10.1172/JCI14276 . PMC 150992 PMID 12045255 . Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats" (PDF) . J. Am. Soc. Nephrol . 18 (6): 1789–95. doi :10.1681/ASN.2006091062 PMID 17494887 . Schefe JH, Menk M, Reinemund J, et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein" . Circ. Res . 99 (12): 1355–66. CiteSeerX 10.1.1.486.8053 doi :10.1161/01.RES.0000251700.00994.0d PMID 17082479 . Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats" . Kidney Int . 70 (4): 641–6. doi :10.1038/sj.ki.5001627 PMID 16807542 . Burcklé CA, Jan Danser AH, Müller DN, et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats" . Hypertension . 47 (3): 552–6. doi :10.1161/01.HYP.0000199912.47657.04 PMID 16401765 . Huang Y, Wongamorntham S, Kasting J, et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms" . Kidney Int . 69 (1): 105–13. doi :10.1038/sj.ki.5000011 PMID 16374430 . Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26. doi :10.1093/dnares/12.2.117 PMID 16303743 . Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet . 14 (8): 1019–27. doi :10.1093/hmg/ddi094 . PMID 15746149 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol . 51 (1): 45–50. doi :10.1002/ana.10051 . hdl :2027.42/34887 PMID 11782983 . S2CID 18107509 . Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning" . Proc. Natl. Acad. Sci. U.S.A . 97 (17): 9543–8. Bibcode :2000PNAS...97.9543H . doi :10.1073/pnas.160270997 PMC 16901 PMID 10931946 .
