Protein-coding gene in the species Homo sapiens
Borealin is a protein that in humans is encoded by the CDCA8 gene .[ 5] [ 6] [ 7]
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[ 7] [ 8]
CDCA8 has been shown to interact with INCENP ,[ 8] Survivin [ 6] [ 8] Aurora B kinase .[ 6] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000134690 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028873 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets 1 (1): 73–83. doi :10.2174/1568009013334241 . PMID 12188893 . ^ a b c Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly" . Cell . 118 (2): 187–202. doi :10.1016/j.cell.2004.06.026 PMID 15260989 . ^ a b "Entrez Gene: CDCA8 cell division cycle associated 8" .^ a b c d Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle" . The Journal of Cell Biology . 166 (2): 179–91. doi :10.1083/jcb.200404001 . PMC 2172304 PMID 15249581 . Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle" . Molecular & Cellular Proteomics . 4 (1): 35–43. doi :10.1074/mcp.M400158-MCP200 PMID 15561729 . Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody" . EMBO Reports . 7 (1): 85–92. doi :10.1038/sj.embor.7400562 . PMC 1369225 PMID 16239925 . Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis" . The Journal of Biological Chemistry . 281 (2): 1286–95. doi :10.1074/jbc.M508773200 PMID 16291752 . Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research . 312 (7): 962–73. doi :10.1016/j.yexcr.2005.12.015 . PMID 16427043 . Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres" . Molecular Biology of the Cell . 17 (4): 1897–909. doi :10.1091/mbc.E05-08-0727 . PMC 1415303 PMID 16436504 . Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene . 25 (35): 4867–79. doi :10.1038/sj.onc.1209499 . PMID 16547492 . S2CID 27074707 . Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle" . Proceedings of the National Academy of Sciences of the United States of America . 103 (14): 5391–6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP" . Molecular Biology of the Cell . 17 (6): 2547–58. doi :10.1091/mbc.E05-12-1133 . PMC 1474794 PMID 16571674 . Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin" . BMC Cell Biology . 8 : 5. doi :10.1186/1471-2121-8-5 PMC 1794407 PMID 17241471 . Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis" (PDF) . Cancer Research . 67 (9): 4113–22. doi :10.1158/0008-5472.CAN-06-4705 PMID 17483322 .
