CCNG2

CCNG2
Identifiers
AliasesCCNG2, cyclin G2
External IDsOMIM: 603203; MGI: 1095734; HomoloGene: 3208; GeneCards: CCNG2; OMA:CCNG2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004354

NM_007635

RefSeq (protein)

NP_004345

NP_031661

Location (UCSC)Chr 4: 77.16 – 77.43 MbChr 5: 93.42 – 93.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.[5][6]

Function

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The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.[6]

Interactions

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CCNG2 has been shown to interact with PPP2CA.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138764Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029385Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.
  6. ^ a b "Entrez Gene: CCNG2 cyclin G2".
  7. ^ Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (Jul 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.
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Further reading

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