List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.[1] The database is developed and maintained by Andrew McDonald.[2]

EC 1.1 Acting on the CH-OH group of donors

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EC 1.1.1 With Nicotinamide adenine dinucleotide or NADP as acceptor

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At present (October 2021) most of the entries from 343 onwards have no Wikipedia articles
  • EC 1.1.1.343: phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
  • EC 1.1.1.344: dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
  • EC 1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)
  • EC 1.1.1.346: 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
  • EC 1.1.1.347: geraniol dehydrogenase (NAD+)
  • EC 1.1.1.348: (3R)-2′-hydroxyisoflavanone reductase
  • EC 1.1.1.349: norsolorinic acid ketoreductase
  • EC 1.1.1.350: ureidoglycolate dehydrogenase (NAD+)
  • EC 1.1.1.351: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
  • EC 1.1.1.352: 5′-hydroxyaverantin dehydrogenase
  • EC 1.1.1.353: versiconal hemiacetal acetate reductase
  • EC 1.1.1.354: farnesol dehydrogenase (NAD+)
  • EC 1.1.1.355: 2′-dehydrokanamycin reductase
  • EC 1.1.1.356: GDP-L-colitose synthase
  • EC 1.1.1.357: 3α-hydroxysteroid 3-dehydrogenase
  • EC 1.1.1.358: 2-dehydropantolactone reductase
  • EC 1.1.1.359: aldose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.360: glucose/galactose 1-dehydrogenase
  • EC 1.1.1.361: glucose-6-phosphate 3-dehydrogenase
  • EC 1.1.1.362: aklaviketone reductase
  • EC 1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+]
  • EC 1.1.1.364: dTDP-4-dehydro-6-deoxy-α-D-gulose 4-ketoreductase
  • EC 1.1.1.365: D-galacturonate reductase
  • EC 1.1.1.366: L-idonate 5-dehydrogenase (NAD+)
  • EC 1.1.1.367: UDP-2-acetamido-2,6-β-L-arabino-hexul-4-ose reductase
  • EC 1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
  • EC 1.1.1.369: D-chiro-inositol 1-dehydrogenase
  • EC 1.1.1.370: scyllo-inositol 2-dehydrogenase (NAD+)
  • EC 1.1.1.371: scyllo-inositol 2-dehydrogenase (NADP+)
  • EC 1.1.1.372: D/L-glyceraldehyde reductase
  • EC 1.1.1.373: sulfolactaldehyde 3-reductase
  • EC 1.1.1.374: UDP-N-acetylglucosamine 3-dehydrogenase
  • EC 1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
  • EC 1.1.1.376: L-arabinose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.377: L-rhamnose 1-dehydrogenase (NADP+)
  • EC 1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+]
  • EC 1.1.1.379: (R)-mandelate dehydrogenase
  • EC 1.1.1.380: L-gulonate 5-dehydrogenase
  • EC 1.1.1.381: 3-hydroxy acid dehydrogenase
  • EC 1.1.1.382: ketol-acid reductoisomerase (NAD+)
  • EC 1.1.1.383: ketol-acid reductoisomerase [NAD(P)+]
  • EC 1.1.1.384: dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase
  • EC 1.1.1.385: dihydroanticapsin dehydrogenase
  • EC 1.1.1.386: ipsdienol dehydrogenase
  • EC 1.1.1.387: L-serine 3-dehydrogenase (NAD+)
  • EC 1.1.1.388: glucose-6-phosphate dehydrogenase (NAD+)
  • EC 1.1.1.389: 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase
  • EC 1.1.1.390: sulfoquinovose 1-dehydrogenase
  • EC 1.1.1.391: 3β-hydroxycholanate 3-dehydrogenase (NAD+)
  • EC 1.1.1.392: 3α-hydroxycholanate dehydrogenase (NADP+)
  • EC 1.1.1.393: 3β-hydroxycholanate 3-dehydrogenase (NADP+)
  • EC 1.1.1.394: aurachin B dehydrogenase
  • EC 1.1.1.395: 3α-hydroxy bile acid-CoA-ester 3-dehydrogenase
  • EC 1.1.1.396: bacteriochlorophyllide a dehydrogenase
  • EC 1.1.1.397: β-methylindole-3-pyruvate reductase
  • EC 1.1.1.398: 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase
  • EC 1.1.1.399: 2-oxoglutarate reductase
  • EC 1.1.1.400: 2-methyl-1,2-propanediol dehydrogenase
  • EC 1.1.1.401: 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)
  • EC 1.1.1.402: D-erythritol 1-phosphate dehydrogenase
  • EC 1.1.1.403: D-threitol dehydrogenase (NAD+)
  • EC 1.1.1.404: tetrachlorobenzoquinone reductase
  • EC 1.1.1.405: ribitol-5-phosphate 2-dehydrogenase (NADP+)
  • EC 1.1.1.406: galactitol 2-dehydrogenase (L-tagatose-forming)
  • EC 1.1.1.407: D-altritol 5-dehydrogenase
  • EC 1.1.1.408: 4-phospho-D-threonate 3-dehydrogenase
  • EC 1.1.1.409: 4-phospho-D-erythronate 3-dehydrogenase
  • EC 1.1.1.410: D-erythronate 2-dehydrogenase
  • EC 1.1.1.411: L-threonate 2-dehydrogenase
  • EC 1.1.1.412: 2-alkyl-3-oxoalkanoate reductase
  • EC 1.1.1.413: A-factor type γ-butyrolactone 1′-reductase (1S-forming)
  • EC 1.1.1.414: L-galactonate 5-dehydrogenase
  • EC 1.1.1.415: noscapine synthase
  • EC 1.1.1.416: isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
  • EC 1.1.1.417: 3β-hydroxysteroid-4β-carboxylate 3-dehydrogenase (decarboxylating)
  • EC 1.1.1.418: plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating)
  • EC 1.1.1.419: nepetalactol dehydrogenase
  • EC 1.1.1.420: D-apiose dehydrogenase
  • EC 1.1.1.421: D-apionate oxidoisomerase
  • EC 1.1.1.422: pseudoephedrine dehydrogenase
  • EC 1.1.1.423: (1R,2S)-ephedrine 1-dehydrogenase
  • EC 1.1.1.424: D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
  • EC 1.1.1.425: levoglucosan dehydrogenase
  • EC 1.1.1.426: UDP-N-acetyl-α-D-quinovosamine dehydrogenase

EC 1.1.2 With a cytochrome as acceptor

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*No Wikipedia article

EC 1.1.3 With oxygen as acceptor

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*No Wikipedia article

EC 1.1.4 With a disulfide as acceptor

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  • EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)
  • EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.1.5 With a quinone or similar compound as acceptor

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EC 1.1.9 With a copper protein as acceptor

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EC 1.1.98 With other, known, acceptors

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*No Wikipedia article

EC 1.1.99 With unknown physiological acceptors

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*No Wikipedia article

EC 1.2 Acting on the aldehyde or oxo group of donors

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EC 1.2.1 With NAD+ or NADP+ as acceptor

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* No Wikipedia article

EC 1.2.2 With a cytochrome as acceptor

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  • EC 1.2.2.1: formate dehydrogenase (cytochrome)
  • EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone)
  • EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase (cytochrome-c-553)
  • EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase

EC 1.2.3 With oxygen as acceptor

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* No Wikipedia article

EC 1.2.4 With a disulfide as acceptor

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EC 1.2.5 With a quinone or similar compound as acceptor

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*No Wikipedia article

EC 1.2.7 With an iron–sulfur protein as acceptor

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*No Wikipedia article

EC 1.2.99: With unknown physiological acceptors

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  • EC 1.2.99.1: Now EC 1.17.99.4, uracil/thymine dehydrogenase
  • EC 1.2.99.2: Now EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin)
  • EC 1.2.99.3: Now EC 1.2.5.2, aldehyde dehydrogenase (quinone)
  • EC 1.2.99.4: Now EC 1.2.98.1, formaldehyde dismutase
  • EC 1.2.99.5: Now EC 1.2.7.12, formylmethanofuran dehydrogenase
  • EC 1.2.99.6: carboxylate reductase
  • EC 1.2.99.7: aldehyde dehydrogenase (FAD-independent)
  • EC 1.2.99.8: glyceraldehyde dehydrogenase (FAD-containing) *
  • EC 1.2.99.9: Now EC 1.17.98.3, formate dehydrogenase (coenzyme F420)
  • EC 1.2.99.10: 4,4′-diapolycopenoate synthase *
*No Wikipedia article

EC 1.3 Acting on the CH-CH group of donors

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EC 1.3.1 With NAD+ or NADP+ as acceptor

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*No Wikipedia article

EC 1.3.2 With a cytochrome as acceptor

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EC 1.3.3 With oxygen as acceptor

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EC 1.3.7 With an iron–sulfur protein as acceptor

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EC 1.3.8 With a flavin as acceptor

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*No Wikipedia article

EC 1.3.98 With FMN acceptor

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  • EC 1.3.98.1: dihydroorotate dehydrogenase (fumarate)
  • EC 1.3.98.2: Now EC 1.3.4.1, fumarate reductase (CoM/CoB)
  • EC 1.3.98.3: coproporphyrinogen dehydrogenase *
  • EC 1.3.98.4: 5a,11a-dehydrotetracycline reductase *
  • EC 1.3.98.5: hydrogen peroxide-dependent heme synthase *
  • EC 1.3.98.6: AdoMet-dependent heme synthase *
  • EC 1.3.98.7: [mycofactocin precursor peptide]-tyrosine decarboxylase
*No Wikipedia article

EC 1.3.99 With unknown physiological acceptors

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*No Wikipedia article

EC 1.4 Acting on the CH-NH2 group of donors

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EC 1.4.1 With NAD+ or NADP+ as acceptor

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*No Wikipedia article

EC 1.4.2 With a cytochrome as acceptor

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EC 1.4.3 With oxygen as acceptor

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*No Wikipedia article

EC 1.4.4 With a disulfide as acceptor

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EC 1.4.5 With a quinone or other compound as acceptor

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EC 1.4.7 With an iron–sulfur protein as acceptor

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EC 1.4.9 With a copper protein as acceptor

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EC 1.4.98 With tryptophan tryptophylquinone acceptors

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EC 1.4.99 With unknown physiological acceptors

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*No Wikipedia article

EC 1.5 Acting on the CH-NH group of donors

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EC 1.5.1 With NAD+ or NADP+ as acceptor

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*No Wikipedia article

EC 1.5.3 With oxygen as acceptor

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*No Wikipedia article

EC 1.5.4 With a disulfide as acceptor

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EC 1.5.5 With a quinone or similar compound as acceptor

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*No Wikipedia article

EC 1.5.7 With an iron–sulfur protein as acceptor

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*No Wikipedia article

EC 1.5.8 With a flavin or flavoprotein as acceptor

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EC 1.5.98 With other, known, physiological acceptors

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  • EC 1.5.98.1: ethylenetetrahydromethanopterin dehydrogenase
  • EC 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase
  • EC 1.5.98.3: coenzyme F420:methanophenazine dehydrogenase

EC 1.5.99 With unknown physiological acceptors

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*No Wikipedia article

EC 1.6 Acting on NADH or NADPH

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EC 1.6.1 With NAD or NADP as acceptor

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EC 1.6.2 With a heme protein as acceptor

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EC 1.6.3 With oxygen as acceptor

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*No Wikipedia article

EC 1.6.4 With a disulfide as acceptor (deleted sub-class)

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  • EC 1.6.4.1: now EC 1.8.1.6 cystine reductase
  • EC 1.6.4.2: now EC 1.8.1.7 glutathione-disulfide reductase
  • EC 1.6.4.3: now EC 1.8.1.4 dihydrolipoyl dehydrogenase
  • EC 1.6.4.4: now EC 1.8.1.8 protein-disulfide reductase
  • EC 1.6.4.5: now EC 1.8.1.9 thioredoxin-disulfide reductase
  • EC 1.6.4.6: now EC 1.8.1.10 CoA-glutathione reductase
  • EC 1.6.4.7: now EC 1.8.1.11 asparagusate reductase
  • EC 1.6.4.8: now EC 1.8.1.12 trypanothione-disulfide reductase
  • EC 1.6.4.9: now EC 1.8.1.13 bis-γ-glutamylcystine reductase
  • EC 1.6.4.10: now EC 1.8.1.14 CoA-disulfide reductase

EC 1.6.5 With a quinone or similar compound as acceptor

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*No Wikipedia article

EC 1.6.6 With a nitrogenous group as acceptor

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  • EC 1.6.6.1: Now EC 1.7.1.1, nitrate reductase (NADH)
  • EC 1.6.6.2: Now EC 1.7.1.2, nitrate reductase [NAD(P)H]
  • EC 1.6.6.3: Now EC 1.7.1.3, nitrate reductase (NADPH)
  • EC 1.6.6.4: Now EC 1.7.1.4, nitrite reductase [NAD(P)H]
  • EC 1.6.6.5: Now EC 1.7.2.1, nitrite reductase (NO-forming)
  • EC 1.6.6.6: Now EC 1.7.1.5, hyponitrite reductase
  • EC 1.6.6.7: Now EC 1.7.1.6, azobenzene reductase
  • EC 1.6.6.8: Now EC 1.7.1.7, GMP reductase
  • EC 1.6.6.9: Now known to be catalysed by EC 1.7.2.3, trimethylamine-N-oxide reductase
  • EC 1.6.6.10: Now EC 1.7.1.9, nitroquinoline-N-oxide reductase]
  • EC 1.6.6.11: Now EC 1.7.1.10, hydroxylamine reductase (NADH)
  • EC 1.6.6.12: Now EC 1.7.1.11, 4-(dimethylamino)phenylazoxybenzene reductase
  • EC 1.6.6.13: Now EC 1.7.1.12, N-hydroxy-2-acetamidofluorene reductase

EC 1.6.7 With an iron–sulfur protein as acceptor (deleted sub-subclass)

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  • EC 1.6.7.1: now EC 1.18.1.2 ferredoxin—NADP+ reductase
  • EC 1.6.7.2: now EC 1.18.1.1 rubredoxin—NAD+ reductase
  • EC 1.6.7.3: now EC 1.18.1.3 ferredoxin—NAD+ reductase

EC 1.6.8 With a flavin as acceptor (deleted sub-subclass)

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EC 1.6.99 With unknown physiological acceptors

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  • EC 1.6.99.1: NADPH dehydrogenase
  • EC 1.6.99.2: Now EC 1.6.5.2, NAD(P)H dehydrogenase (quinone
  • EC 1.6.99.3: The activity is covered by EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)
  • EC 1.6.99.4: Now EC 1.18.1.2, ferredoxin—NADP+ reductase
  • EC 1.6.99.5: Now EC 1.6.5.11, NADH dehydrogenase (quinone)
  • EC 1.6.99.6: Now EC 1.6.5.10, NADPH dehydrogenase (quinone)
  • EC 1.6.99.7: Now EC 1.5.1.34, 6,7-dihydropteridine reductase
  • EC 1.6.99.8: Deleted
  • EC 1.6.99.9: Now EC 1.16.1.4, cob(II)alamin reductase
  • EC 1.6.99.10: included in EC 1.5.1.34, 6,7-dihydropteridine reductase
  • EC 1.6.99.11: Deleted
  • EC 1.6.99.12: Now EC 1.16.1.6, cyanocobalamin reductase (cyanide-eliminating)
  • EC 1.6.99.13: Now EC 1.16.1.7, ferric-chelate reductase

EC 1.7 Acting on other nitrogenous compounds as donors

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EC 1.7.1 With NAD+ or NADP+ as acceptor

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EC 1.7.2 With a cytochrome as acceptor

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*No Wikipedia article

EC 1.7.3 With oxygen as acceptor

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*No Wikipedia article

EC 1.7.5 With a quinone or similar compound as acceptor

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EC 1.7.6 With a nitrogenous group as acceptor

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EC 1.7.7 With an iron–sulfur protein as acceptor

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EC 1.7.99 With other acceptors

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EC 1.8 Acting on a sulfur group of donors

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EC 1.8.1 With NAD+ or NADP+ as acceptor

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*No Wikipedia article

EC 1.8.2 With a cytochrome as acceptor

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*No Wikipedia article

EC 1.8.3 With oxygen as acceptor

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*No Wikipedia article

EC 1.8.4 With a disulfide as acceptor

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*No Wikipedia article

EC 1.8.5 With a quinone or similar compound as acceptor

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*No Wikipedia article

EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

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EC 1.8.7 With an iron–sulfur protein as acceptor

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*No Wikipedia article

EC 1.8.98 With other, known, acceptors

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EC 1.8.99 With other acceptors

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  • EC 1.8.99.1: Now covered by EC 1.8.1.2, assimilatory sulfite reductase (NADPH) and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin)
  • EC 1.8.99.2: adenylyl-sulfate reductase
  • EC 1.8.99.3: an in vitro artifact of EC 1.8.99.5, dissimilatory sulfite reductase
  • EC 1.8.99.4: Now EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin)
  • EC 1.8.99.5: dissimilatory sulfite reductase *
*No Wikipedia article

EC 1.9 Acting on a heme group of donors

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EC 1.9.3 With oxygen as acceptor

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  • EC 1.9.3.1: Now EC 7.1.1.9, cytochrome-c oxidase
  • EC 1.9.3.2: Now included with EC 1.7.2.1, nitrite reductase (NO-forming)

EC 1.9.6 With a nitrogenous group as acceptor

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EC 1.9.98 With other, known, physiological acceptors

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EC 1.9.99 With other acceptors

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  • EC 1.9.99.1: Now EC 1.9.98.1, iron—cytochrome-c reductase
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EC 1.10.1 With NAD+ or NADP+ as acceptor

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EC 1.10.2 With a cytochrome as acceptor

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  • EC 1.10.2.1: The activity is covered by EC 7.2.1.3, ascorbate ferrireductase (transmembrane)
  • EC 1.10.2.2: Now EC 7.1.1.8, quinol—cytochrome-c reductase

EC 1.10.3 With oxygen as acceptor

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*No Wikipedia article
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  • EC 1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)
*No Wikipedia article

EC 1.10.9 With a copper protein as acceptor

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  • EC 1.10.9.1: Now EC 7.1.1.6, plastoquinol—plastocyanin reductase

EC 1.10.99 With unknown physiological acceptors

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  • EC 1.10.99.1: Now EC 1.10.9.1 plastoquinol—plastocyanin reductase
  • EC 1.10.99.2: Now EC 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)
  • EC 1.10.99.3: Now EC 1.23.5.1 violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor

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EC 1.11.1 Peroxidases

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*No Wikipedia article

EC 1.11.2 Peroxygenase

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*No Wikipedia article

EC 1.12 Acting on hydrogen as donor

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EC 1.12.1 With NAD+ or NADP+ as acceptor

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*No Wikipedia article

EC 1.12.2 With a cytochrome as acceptor

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EC 1.12.5 With a quinone or similar compound as acceptor

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EC 1.12.7 With an iron–sulfur protein as acceptor

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EC 1.12.98 With other known acceptors

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EC 1.12.99 With unknown physiological acceptors

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EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

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EC 1.13.11 With incorporation of two atoms of oxygen

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*No Wikipedia article

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

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*No Wikipedia article

EC 1.13.99 Miscellaneous

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EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

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EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

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  • EC 1.14.1.1: now EC 1.14.14.1, unspecific monooxygenase
  • EC 1.14.1.2: now EC 1.14.13.9, kynurenine 3-monooxygenase
  • EC 1.14.1.3: deleted, covered by EC 1.14.99.7, squalene monooxygenase and EC 5.4.99.7, lanosterol synthase
  • EC 1.14.1.4: now EC 1.14.99.2, kynurenine 7,8-hydroxylase
  • EC 1.14.1.5: now EC 1.14.13.5; imidazoleacetate 4-monooxygenase
  • EC 1.14.1.6: now EC 1.14.15.4, steroid 11β-monooxygenase
  • EC 1.14.1.7: now EC 1.14.99.9, steroid 17α-monooxygenase
  • EC 1.14.1.8: now EC 1.14.99.10, steroid 21-monooxygenase
  • EC 1.14.1.9: deleted
  • EC 1.14.1.10: now EC 1.14.99.11 estradiol 6β-monooxygenase
  • EC 1.14.1.11: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)

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  • EC 1.14.2.1: now EC 1.14.17.1, dopamine β-monooxygenase
  • EC 1.14.2.2: now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

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  • EC 1.14.3.1: now EC 1.14.16.1, phenylalanine 4-monooxygenase

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

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EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

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*No Wikipedia article

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

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