Elmo domain containing 2 Protein-coding gene in the species Homo sapiens ELMOD2IdentifiersAliasesELMOD2, 9830169G11Rik, ELMO domain containing 2External IDsOMIM: 610196; MGI: 2445165; HomoloGene: 16662; GeneCards: ELMOD2; OMA:ELMOD2 - orthologsGene location (Human)Chr.Chromosome 4 (human)[1]Band4q31.1Start140,524,168 bp[1]End140,553,770 bp[1]Gene location (Mouse)Chr.Chromosome 8 (mouse)[2]Band8|8 C2Start84,039,261 bp[2]End84,059,115 bp[2]RNA expression patternBgeeHumanMouse (ortholog)Top expressed inAchilles tendonmucosa of ileumrenal medullalateral nuclear group of thalamusspinal gangliacardiatrigeminal ganglionmucosa of paranasal sinusjejunal mucosanasal epitheliumTop expressed inprimary oocyteotic vesiclesecondary oocytezygoteotolith organutricleEpithelium of choroid plexushandretinal pigment epitheliummedullary collecting ductMore reference expression dataBioGPSn/aGene ontologyMolecular function GTPase activator activity Cellular component membrane Biological process defense response to virus regulation of defense response to virus positive regulation of GTPase activity Sources:Amigo / QuickGOOrthologsSpeciesHumanMouseEntrez255520244548EnsemblENSG00000179387ENSMUSG00000035151UniProtQ8IZ81Q8BGF6RefSeq (mRNA)NM_153702NM_001170691NM_178736RefSeq (protein)NP_714913NP_001164162NP_848851Location (UCSC)Chr 4: 140.52 – 140.55 MbChr 8: 84.04 – 84.06 MbPubMed search[3][4]WikidataView/Edit HumanView/Edit Mouse ELMO domain containing 2 is a protein that in humans is encoded by the ELMOD2 gene. [5] Function[edit] This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. References[edit] ^ a b c GRCh38: Ensembl release 89: ENSG00000179387 – Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035151 – Ensembl, May 2017 ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Entrez Gene: ELMO domain containing 2". Retrieved 2016-08-29. Further reading[edit] Hodgson U, Pulkkinen V, Dixon M, Peyrard-Janvid M, Rehn M, Lahermo P, Ollikainen V, Salmenkivi K, Kinnula V, Kere J, Tukiainen P, Laitinen T (2006). "ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis". Am. J. Hum. Genet. 79 (1): 149–54. doi:10.1086/504639. PMC 1474126. PMID 16773575. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.vte