Histidine methyl ester

Histidine methyl ester
Names
Other names
Methyl L-histidinate, HME
Identifiers
3D model (JSmol)
957974
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.014.645 Edit this at Wikidata
EC Number
  • 216-109-3
UNII
  • InChI=1S/C7H11N3O2/c1-12-7(11)6(8)2-5-3-9-4-10-5/h3-4,6H,2,8H2,1H3,(H,9,10)/t6-/m0/s1
    Key: BXRMEWOQUXOLDH-LURJTMIESA-N
  • COC(=O)[C@H](Cc1c[nH]cn1)N
Properties
C7H11N3O2
Molar mass 169.184 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Histidine methyl ester (HME) is an irreversible histidine decarboxylase inhibitor.[1][2][3] It is the methyl ester of histidine.

HME bound to histidine decarboxylase

See also

[edit]

References

[edit]
  1. ^ Lane, Roger S; Manning, James M; Snell, Esmond E (2002). "Histidine decarboxylase of lactobacillus 30a: inactivation and active-site labeling by L-histidine methyl ester". Biochemistry. 15 (19): 4180–5. doi:10.1021/bi00664a008. PMID 963031.
  2. ^ Alston, Theodore A; Abeles, Robert H (2002). "Reaction of Lactobacillus histidine decarboxylase with L-histidine methyl ester". Biochemistry. 26 (13): 4082–5. doi:10.1021/bi00387a051. PMID 3651438.
  3. ^ Komori, H; Nitta, Y; Ueno, H; Higuchi, Y (2012). "Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase". The Journal of Biological Chemistry. 287 (34): 29175–83. doi:10.1074/jbc.M112.381897. PMC 3436558. PMID 22767596.


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