MMP26

MMP26
Identifiers
AliasesMMP26, matrix metallopeptidase 26
External IDsOMIM: 605470; HomoloGene: 49684; GeneCards: MMP26; OMA:MMP26 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021801
NM_001384608

n/a

RefSeq (protein)

NP_068573

n/a

Location (UCSC)Chr 11: 4.7 – 4.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Matrix metalloproteinase-26 also known as matrilysin-2 and endometase is an enzyme that in humans is encoded by the MMP26 gene.[3][4][5]

Function

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin (A1AT), alpha 2-macroglobulin (A2M), and insulin-like growth factor-binding protein 1 (IGFBP), and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167346Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Park HI, Ni J, Gerkema FE, Liu D, Belozerov VE, Sang QX (Aug 2000). "Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor". J Biol Chem. 275 (27): 20540–4. doi:10.1074/jbc.M002349200. PMID 10801841.
  4. ^ de Coignac AB, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry JP, Berthier O, Schmitt D, Bonnefoy JY, Gauchat JF (Jul 2000). "Cloning of MMP-26. A novel matrilysin-like proteinase". Eur J Biochem. 267 (11): 3323–9. doi:10.1046/j.1432-1327.2000.01363.x. PMID 10824119.
  5. ^ a b "Entrez Gene: MMP26 matrix metallopeptidase 26".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: M10.029