NBR1

NBR1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WJ6, 2BKF, 2CP8, 2G4S, 2L8J, 2MGW, 2MJ5, 4OLE

Identifiers

NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor

External IDs

OMIM: 166945; MGI: 108498; HomoloGene: 7438; GeneCards: NBR1; OMA:NBR1 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.31	Start	43,170,481 bp^[1]
Band	17q21.31	End	43,211,689 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 D\|11 65.36 cM	Start	101,442,975 bp^[2]
Band	11 D\|11 65.36 cM	End	101,472,777 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

amniotic fluid

parietal pleura

epithelium of nasopharynx

germinal epithelium

Epithelium of choroid plexus

internal globus pallidus

jejunal mucosa

palpebral conjunctiva

visceral pleura

Top expressed in

ciliary body

retinal pigment epithelium

spermatid

seminiferous tubule

lacrimal gland

utricle

iris

pituitary gland

motor neuron

sciatic nerve

More reference expression data

n/a

Gene ontology
Molecular function	metal ion binding zinc ion binding protein binding mitogen-activated protein kinase binding ubiquitin binding
Cellular component	cytoplasm M band autophagosome cytosol late endosome lysosome extracellular exosome membrane cytoplasmic vesicle phagophore assembly site mitochondrion nucleoplasm nuclear body intracellular membrane-bounded organelle
Biological process	protein complex oligomerization negative regulation of osteoblast differentiation regulation of stress-activated MAPK cascade regulation of bone mineralization macroautophagy
Sources:Amigo / QuickGO

Species

Human

Mouse


4077


17966


ENSG00000188554


ENSMUSG00000017119


Q14596


P97432

RefSeq (mRNA)


NM_001291571 NM_001291572 NM_005899 NM_031858 NM_031862


NM_001252220 NM_001252222 NM_001252223 NM_008676

RefSeq (protein)


NP_001278500 NP_001278501 NP_005890 NP_114068


NP_001239149 NP_001239151 NP_001239152 NP_032702

Location (UCSC)

Chr 17: 43.17 – 43.21 Mb

Chr 11: 101.44 – 101.47 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.^[5]^[6]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.^[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.^[7]

Interactions

NBR1 has been shown to interact with FEZ1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188554 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
^ ^a ^b "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
^ Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34 (3): 259–269. doi:10.1016/j.molcel.2009.04.026. PMID 19450525.
^ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading

Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science.7545954. PMID 7545954.
Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
Brown MA, Nicolai H, Xu CF, et al. (1995). "Regulation of BRCA1". Nature. 372 (6508): 733. Bibcode:1994Natur.372..733B. doi:10.1038/372733a0. PMID 7997258. S2CID 40825012.
Brown MA, Xu CF, Nicolai H, et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene. 12 (12): 2507–13. PMID 8700509.
Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene. 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671.
Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lamark T, Perander M, Outzen H, et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–1603. Bibcode:2005Sci...308.1599L. CiteSeerX 10.1.1.383.9888. doi:10.1126/science.1110463. PMID 15802564. S2CID 2809403.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

v t e PDB gallery
1wj6: Solution structure of RSGI RUH-024, a PB1 domain in human cDNA, KIAA0049 2bkf: STRUCTURE OF THE PB1 DOMAIN OF NBR1 2cp8: Solution structure of the RSGI RUH-046, a UBA domain from human Next to BRCA1 gene 1 protein (KIAA0049 protein) R923H variant 2g4s: Anomalous substructure of NBR1PB1

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