Odorant-binding protein 2A

OBP2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RUN
Identifiers
Aliases	OBP2A, LCN13, OBP, OBP2C, OBPIIa, hOBPIIa, odorant binding protein 2A
External IDs	OMIM: 164320; MGI: 3651927; HomoloGene: 135821; GeneCards: OBP2A; OMA:OBP2A - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	135,549,969 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,630,109 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; skin of leg; ; caput epididymis; ; skin of abdomen; ; testicle; ; right testis; ; left testis; ; bone; ; placenta; ; bone marrow;
	Top expressed in
	embryo; ; hypothalamus; ; striatum of neuraxis; ; olfactory bulb; ; pancreas; ; islet of Langerhans; ; dentate gyrus of hippocampal formation granule cell; ; Cortex of frontal lobe; ; superior frontal gyrus; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	odorant binding; small molecule binding;
Cellular component	extracellular region; cellular component;
Biological process	sensory perception of chemical stimulus; sensory perception of smell; response to stimulus;
	Sources:Amigo / QuickGO
Orthologs
	29991
	383678
	ENSG00000122136
	ENSMUSG00000079539
	Q9NY56
	A2BHR0
	NM_001293189; NM_001293193; NM_014582
	NM_001099301; NM_001378280
	NP_001280118; NP_001280122; NP_055397
	NP_001365209
	Wikidata
View/Edit Human	View/Edit Mouse

Odorant-binding protein 2a is a protein that in humans is encoded by the OBP2A gene.^[5]

This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122136 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079539 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OBP2A odorant binding protein 2A".

Tegoni M, Pelosi P, Vincent F, et al. (2000). "Mammalian odorant binding proteins". Biochim. Biophys. Acta. 1482 (1–2): 229–40. doi:10.1016/S0167-4838(00)00167-9. PMID 11058764.
Tcatchoff L, Nespoulous C, Pernollet JC, Briand L (2006). "A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes". FEBS Lett. 580 (8): 2102–8. doi:10.1016/j.febslet.2006.03.017. PMID 16546182. S2CID 13269549.
Breustedt DA, Schönfeld DL, Skerra A (2006). "Comparative ligand-binding analysis of ten human lipocalins". Biochim. Biophys. Acta. 1764 (2): 161–73. doi:10.1016/j.bbapap.2005.12.006. PMID 16461020.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Matarazzo V, Zsürger N, Guillemot JC, et al. (2003). "Porcine odorant-binding protein selectively binds to a human olfactory receptor". Chem. Senses. 27 (8): 691–701. doi:10.1093/chemse/27.8.691. PMID 12379593.
Briand L, Eloit C, Nespoulous C, et al. (2002). "Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties". Biochemistry. 41 (23): 7241–52. doi:10.1021/bi015916c. PMID 12044155.
Lacazette E, Gachon AM, Pitiot G (2000). "A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres". Hum. Mol. Genet. 9 (2): 289–301. doi:10.1093/hmg/9.2.289. PMID 10607840.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122136 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079539 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OBP2A odorant binding protein 2A".

[1]

[2]

[3]

[4]

[5]

Odorant-binding protein 2A

References

Further reading

€4.95