PCDH20

PCDH20
Identifiers
Aliases	PCDH20, PCDH13, protocadherin 20
External IDs	OMIM: 614449; MGI: 2443376; HomoloGene: 11277; GeneCards: PCDH20; OMA:PCDH20 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	61,415,522 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	88,708,832 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; testicle; ; prefrontal cortex; ; hippocampus proper; ; popliteal artery; ; tibial arteries; ; Achilles tendon; ; Brodmann area 9; ; anterior cingulate cortex; ; Descending thoracic aorta;
	Top expressed in
	utricle; ; vestibular sensory epithelium; ; vestibular membrane of cochlear duct; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; lumbar subsegment of spinal cord; ; endolymphatic duct; ; Region I of hippocampus proper; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; RNA binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	64881
	219257
	ENSG00000280165
	ENSMUSG00000050505
	Q8N6Y1
	Q8BIZ0
	NM_022843
	NM_178685
	NP_073754
	NP_848800
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-20 is a protein that in humans is encoded by the PCDH20 gene.^[5]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000280165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050505 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PCDH20 protocadherin 20".

Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000280165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050505 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PCDH20 protocadherin 20".

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PCDH20

References

Further reading

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