Protein-coding gene in the species Homo sapiens
Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene .[ 3] [ 4]
The protein encoded by this gene is a proline -rich salivary protein. It is a major constituent of parotid saliva . This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.[ 4]
Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 17 . pp. 141–99. doi :10.1007/978-1-4613-0987-1_5 . ISBN 978-1-4612-8279-2 PMID 3055850 . Azen EA, Minaguchi K, Latreille P, Kim HS (1990). "Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew" . Am. J. Hum. Genet . 47 (4): 686–97. PMC 1683781 PMID 2171329 . Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over" . Genetics . 120 (1): 267–78. doi :10.1093/genetics/120.1.267 . PMC 1203497 PMID 2851479 . Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system" . J. Biol. Chem . 260 (20): 11123–30. doi :10.1016/S0021-9258(17)39156-1 PMID 2993301 . Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 . Azen E, Prakobphol A, Fisher SJ (1993). "PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro" . Infect. Immun . 61 (10): 4434–9. doi :10.1128/IAI.61.10.4434-4439.1993 . PMC 281176 PMID 8406834 . Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491–6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
