PRSS16

PRSS16
Identifiers
Aliases	PRSS16, TSSP, protease, serine 16, serine protease 16
External IDs	OMIM: 607169; MGI: 1859181; HomoloGene: 38106; GeneCards: PRSS16; OMA:PRSS16 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,256,624 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,193,912 bp
RNA expression pattern
	Top expressed in
	thymus; ; body of pancreas; ; mucosa of transverse colon; ; rectum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; palpebral conjunctiva; ; duodenum; ; minor salivary glands;
	Top expressed in
	thymus; ; stroma of bone marrow; ; granulocyte; ; yolk sac; ; morula; ; embryo; ; embryo; ; blastocyst; ; endothelial cell of lymphatic vessel; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; dipeptidyl-peptidase activity;
Cellular component	endosome; lysosome; cytoplasmic vesicle;
Biological process	protein catabolic process; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	10279
	54373
	ENSG00000112812
	ENSMUSG00000006179
	Q9NQE7
	Q9QXE5
	NM_005865
	NM_019429
	NP_005856
	NP_062302
	Wikidata
View/Edit Human	View/Edit Mouse

Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.^[5]^[6]

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.

The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112812 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006179 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
^ ^a ^b "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".

External links

PRSS16 human gene location in the UCSC Genome Browser.
PRSS16 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112812 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006179 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10527559-5] Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.

[entrez-6] "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".

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PRSS16

References

Further reading

External links

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