PTPN3

PTPN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3, protein tyrosine phosphatase non-receptor type 3
External IDsOMIM: 176877; MGI: 105307; HomoloGene: 74451; GeneCards: PTPN3; OMA:PTPN3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011207
NM_001384115

RefSeq (protein)

NP_035337
NP_001371044

Location (UCSC)Chr 9: 109.38 – 109.5 MbChr 4: 57.19 – 57.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.[5][6]

Function

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.[6]

Interactions

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PTPN3 has been shown to interact with YWHAB.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070159Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038764Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yang Q, Tonks NK (August 1991). "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin". Proc Natl Acad Sci USA. 88 (14): 5949–53. Bibcode:1991PNAS...88.5949Y. doi:10.1073/pnas.88.14.5949. PMC 51999. PMID 1648725.
  6. ^ a b "Entrez Gene: PTPN3 protein tyrosine phosphatase, non-receptor type 3".
  7. ^ Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (October 1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. doi:10.1074/jbc.272.43.27281. PMID 9341175.

Further reading

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