Propamidine

Propamidine
Names
	Preferred IUPAC name 4,4′-[Propane-1,3-diylbis(oxy)]di(benzene-1-carboximidamide)
Identifiers
CAS Number	104-32-5 ; 140-63-6 (isethionate) ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:87462 ;
ChEMBL	ChEMBL23013 ;
ChemSpider	58475 ;
ECHA InfoCard	100.002.905
PubChem CID	64949;
UNII	G20G12V769 ; 7T9IJ84C42 (isethionate) ;
CompTox Dashboard (EPA)	DTXSID6048674 ;
	InChI InChI=1S/C17H20N4O2/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21) Key: WTFXJFJYEJZMFO-UHFFFAOYSA-N ; InChI=1/C17H20N4O2/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21) Key: WTFXJFJYEJZMFO-UHFFFAOYAO;
	SMILES O(c1ccc(cc1)C(=[N@H])N)CCCOc2ccc(C(=[N@H])N)cc2;
Properties
Chemical formula	C17H20N4O2
Molar mass	312.373 g·mol−1
Pharmacology
ATC code	D08AC03 (WHO) S01AX15 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Propamidine is an antiseptic and disinfectant.

Propamidine isethionate, the salt of propamidine with isethionic acid, is used in the treatment of Acanthamoeba infection.^[1]

Propamidine is a member of the aromatic diamidine group of compounds which possess bacteriostatic properties against a wide range of organisms. These diamidines exert antibacterial action against pyrogenic cocci, antibiotic resistant staphylococci and some Gram-negative bacilli, the activity of the diamidines being retained in the presence of organic matter such as tissue fluids, pus and serum.^[2]

References

^ Perrine D, Chenu JP, Georges P, Lancelot JC, Saturnino C, Robba M (February 1995). "Amoebicidal efficiencies of various diamidines against two strains of Acanthamoeba polyphaga". Antimicrob. Agents Chemother. 39 (2): 339–42. doi:10.1128/aac.39.2.339. PMC 162538. PMID 7726493.
^ "Brolene Eye Drops - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. Retrieved 2018-11-23.

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

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[pmid7726493-1] Perrine D, Chenu JP, Georges P, Lancelot JC, Saturnino C, Robba M (February 1995). "Amoebicidal efficiencies of various diamidines against two strains of Acanthamoeba polyphaga". Antimicrob. Agents Chemother. 39 (2): 339–42. doi:10.1128/aac.39.2.339. PMC 162538. PMID 7726493.

[2] "Brolene Eye Drops - Summary of Product Characteristics (SmPC) - (eMC)". www.medicines.org.uk. Retrieved 2018-11-23.

[1]

[2]

v t e Antiseptics and disinfectants (D08)
Acridine derivatives	Ethacridine lactate 9-Aminoacridine Euflavine
Biguanides and amidines	Dibrompropamidine Chlorhexidine^# Propamidine Hexamidine Polihexanide
Phenol and derivatives	Hexachlorophene Policresulen Phenol Triclosan Triclocarban Chloroxylenol^# Biphenylol Fenticlor
Nitrofuran derivatives	Nitrofurazone
Iodine products	Iodine/octylphenoxypolyglycolether Povidone-iodine^# Diiodohydroxypropane
Quinoline derivatives	Dequalinium Chlorquinaldol Oxyquinoline Clioquinol
Quaternary ammonium compounds	Benzalkonium Benzethonium chloride Cetrimonium (bromide/chloride) Cetylpyridinium Cetrimide Benzoxonium chloride Didecyldimethylammonium chloride
Mercurial products	Mercuric amidochloride Phenylmercuric borate Mercuric chloride Merbromin Nitromersol Thiomersal Mercuric iodide
Silver compounds	Silver nitrate
Alcohols	Propanol (propyl alcohol) Isopropanol (isopropyl alcohol) Ethanol (ethyl alcohol)^#
Other	Potassium permanganate Sodium hypochlorite Halazone Monalazone Hydrogen peroxide Eosin Chloramine-T (tosylchloramide) Octenidine dihydrochloride
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Names


Preferred IUPAC name 4,4′-[Propane-1,3-diylbis(oxy)]di(benzene-1-carboximidamide)
Identifiers
CAS Number	104-32-5^Y 140-63-6 (isethionate)^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:87462^N
ChEMBL	ChEMBL23013^Y
ChemSpider	58475^Y
ECHA InfoCard	100.002.905
PubChem CID	64949
UNII	G20G12V769^Y 7T9IJ84C42 (isethionate)^Y
CompTox Dashboard (EPA)	DTXSID6048674
InChI InChI=1S/C17H20N4O2/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21)^Y Key: WTFXJFJYEJZMFO-UHFFFAOYSA-N^Y InChI=1/C17H20N4O2/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21) Key: WTFXJFJYEJZMFO-UHFFFAOYAO
SMILES O(c1ccc(cc1)C(=[N@H])N)CCCOc2ccc(C(=[N@H])N)cc2
Properties
Chemical formula	C₁₇H₂₀N₄O₂
Molar mass	312.373 g·mol⁻¹
Pharmacology
ATC code	D08AC03 (WHO) S01AX15 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Propamidine

References

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