Propanamide
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Names | |||
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Preferred IUPAC name Propanamide | |||
Other names n-propylamide Propionamide Propylamide Propionic amide | |||
Identifiers | |||
3D model (JSmol) | |||
ChEBI | |||
ChemSpider | |||
ECHA InfoCard | 100.001.066 | ||
EC Number |
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MeSH | C034666 | ||
PubChem CID | |||
UNII | |||
CompTox Dashboard (EPA) | |||
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Properties | |||
C3H7NO | |||
Molar mass | 73.095 g·mol−1 | ||
Appearance | liquid , yellow | ||
Density | 1.042 g/mL | ||
Melting point | 80 °C (176 °F; 353 K) | ||
Boiling point | 213 °C (415 °F; 486 K) | ||
very soluble in water | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Propanamide has the chemical formula CH3CH2C=O(NH2).[1] It is the amide of propanoic acid.
This organic compound is a mono-substituted amide.[2] Organic compounds of the amide group can react in many different organic processes to form other useful compounds for synthesis.
Preparation
[edit]Propanamide can be prepared by the condensation reaction between urea and propanoic acid:
or by the dehydration of ammonium propionate:
Reactions
[edit]Propanamide being an amide can participate in a Hofmann rearrangement to produce ethylamine gas.
References
[edit]- ^ Ramazani, Ali; Rouhani, Morteza; Joo, Sang Woo (2016-01-01). "Catalyst-free sonosynthesis of highly substituted propanamide derivatives in water". Ultrasonics Sonochemistry. 28: 393–399. doi:10.1016/j.ultsonch.2015.08.019. ISSN 1350-4177. PMID 26384923.
- ^ Ye, Xuewei; Chai, Weiyun; Lian, Xiao-Yuan; Zhang, Zhizhen (2017-06-18). "Novel propanamide analogue and antiproliferative diketopiperazines from mangrove Streptomyces sp. Q24". Natural Product Research. 31 (12): 1390–1396. doi:10.1080/14786419.2016.1253079. ISSN 1478-6419. PMID 27806640. S2CID 24563632.