Protein-coding gene in the species Homo sapiens
Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene .[ 5] [ 6] [ 7] endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.
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Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Cerritelli SM, Crouch RJ (1998). "Cloning, expression, and mapping of ribonucleases H of human and mouse related to bacterial RNase HI" . Genomics . 53 (3): 300–7. doi :10.1006/geno.1998.5497 . PMID 9799596 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cerritelli SM, Frolova EG, Feng C, et al. (2003). "Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice" . Mol. Cell . 11 (3): 807–15. doi :10.1016/S1097-2765(03)00088-1 PMID 12667461 . Lima WF, Rose JB, Nichols JG, et al. (2007). "Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate". Mol. Pharmacol . 71 (1): 83–91. doi :10.1124/mol.106.025015 . PMID 17028158 . S2CID 24995048 . Overview of all the structural information available in the PDB for UniProt : O60930 PDBe-KB .
