Ribose-5-phosphate—ammonia ligase

Ribose-5-phosphate—ammonia ligase
Identifiers
EC no.6.3.4.7
CAS no.9082-52-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a ribose-5-phosphate—ammonia ligase (EC 6.3.4.7) is an enzyme that catalyzes the chemical reaction

ATP + ribose 5-phosphate + NH3 ADP + phosphate + 5-phosphoribosylamine

The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH3, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). This enzyme participates in purine metabolism.

References

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  • Reem GH (November 1968). "Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis". The Journal of Biological Chemistry. 243 (21): 5695–701. PMID 5699059.