SEC61B

SEC61B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEC61B, Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDsOMIM: 609214; MGI: 1913462; HomoloGene: 38229; GeneCards: SEC61B; OMA:SEC61B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006808

NM_024171

RefSeq (protein)

NP_006799

NP_077133

Location (UCSC)Chr 9: 99.22 – 99.23 MbChr 4: 47.47 – 47.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.[5][6][7]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106803Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053317Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
  6. ^ Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
  7. ^ a b "Entrez Gene: SEC61B Sec61 beta subunit".

Further reading

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