STAB2

STAB2
Identifiers
AliasesSTAB2, FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1, stabilin 2
External IDsOMIM: 608561; MGI: 2178743; HomoloGene: 23022; GeneCards: STAB2; OMA:STAB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017564

NM_138673

RefSeq (protein)

NP_060034

NP_619614

Location (UCSC)Chr 12: 103.59 – 103.77 MbChr 10: 86.84 – 87.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.[5][6][7]

Function

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This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on liver sinusoidal endothelial cells, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136011Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035459Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S (February 2002). "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues". The Biochemical Journal. 362 (Pt 1): 155–64. doi:10.1042/0264-6021:3620155. PMC 1222372. PMID 11829752.
  6. ^ Adachi H, Tsujimoto M (September 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". The Journal of Biological Chemistry. 277 (37): 34264–70. doi:10.1074/jbc.M204277200. PMID 12077138.
  7. ^ a b "Entrez Gene: STAB2 stabilin 2".

Further reading

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