XAP044
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| Formula | C15H9IO4 |
| Molar mass | 380.137 g·mol−1 |
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XAP044 is a drug which acts as a potent and selective antagonist of the metabotropic glutamate receptor 7 (mGluR7). It inhibits long-term potentiation in the amygdala and inhibits responses associated with stress and anxiety in animal models,[1] as well as being used to study the role of mGluR7 in various other processes.[2][3][4]
References
[edit]- ^ Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, et al. (April 2014). "Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior". The Journal of Biological Chemistry. 289 (16): 10975–10987. doi:10.1074/jbc.M113.542654. PMC 4036238. PMID 24596089.
- ^ Hajasova Z, Canestrelli C, Acher F, Noble F, Marie N (March 2018). "Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist". Neuropharmacology. 131: 424–430. doi:10.1016/j.neuropharm.2018.01.002. PMID 29307544. S2CID 3391450.
- ^ Gryksa K, Mittmann L, Bauer A, Peterlik D, Flor PJ, Uschold-Schmidt N, Bosch OJ (January 2020). "Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice". Genes, Brain and Behavior. 19 (1): e12627. doi:10.1111/gbb.12627. PMID 31793148. S2CID 208609219.
- ^ Estrela KA, Senninger L, Arndt J, Kabas M, Schmid F, Dillmann L, et al. (June 2022). "Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice". Cells. 11 (11): 1817. doi:10.3390/cells11111817. PMC 9180111. PMID 35681512.
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