The following article presents a summary of the 2000–2001 football season in Venezuela.
Torneo Apertura ("Opening" Tournament)
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| Date | Venue | Opponents | Score | Comp | Venezuela scorers | Fixture [1] |
| 2000-08-10 | Estadio Alejandro Morera Soto
Alajuela, Costa Rica |  Costa Rica | 1 - 5 | F[2] | Urdaneta  2'
Rey 5'
Urdaneta 25'
De Ornelas 62'
Álvarez 89' | 176 |
| 2000-08-16 | Estadio Nacional
Lima, Peru |  Peru | 1 - 0 | WCQ02[3] | | 177 |
| 2000-09-02 | Estadio Defensores del Chaco
Asunción, Paraguay |  Paraguay | 3 - 0 | WCQ02 | | 178 |
| 2000-10-08 | Estadio José Pachencho Romero
Maracaibo, Venezuela |  Brazil | 0 - 6 | WCQ02 | | 179 |
| 2000-11-15 | Estadio José Pachencho Romero
Maracaibo, Venezuela |  Ecuador | 1 - 2 | WCQ02 | Arango 66' | 180 |
| 2001-03-28 | Estadio Monumental
Buenos Aires, Argentina |  Argentina | 5 - 0 | WCQ02 | | 181 |
| 2001-04-19 | Estadio Alejandro Morera Soto
Alajuela, Costa Rica | Costa Rica | 2 - 2 | F | Rondón 61'
Arías 89' (og) | 182 |
| 2001-04-24 | Estadio Pueblo Nuevo
San Cristóbal, Venezuela |  Colombia | 2 - 2 | WCQ02 | Rondón 22'
Arango 81' | 183 |
| 2001-06-01 | Estadio Hernando Siles
La Paz, Bolivia |  Bolivia | 5 - 0 | WCQ02 | | 184 |
| 2001-07-11 | Estadio Metropolitano
Barranquilla, Colombia | Colombia | 2 - 0 | CA01[4] | | 185 |
| 2001-07-14 | Estadio Metropolitano
Barranquilla, Colombia |  Chile | 1 - 0 | CA01 | | 186 |
| 2001-07-17 | Estadio Metropolitano
Barranquilla, Colombia | Ecuador | 4 - 0 | CA01 | | 187 |
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