Allenolic acid
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Formula | C13H12O3 |
Molar mass | 216.236 g·mol−1 |
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Allenolic acid, or allenoic acid, is a synthetic,[1] nonsteroidal estrogen discovered in 1947 or 1948 that, although studied clinically,[2] was never marketed.[3][4][5] It is an open-ring or seco-analogue of steroidal estrogens like estrone and equilenin.[6][7][8] The compound was named after Edgar Allen, one of the pioneers in estrogen research.[9][10] Although described as an estrogen, allenolic acid probably is totally inactive at the receptor, whereas a derivative, allenestrol (α,α-dimethyl-β-ethylallenolic acid), is reported to be a potent estrogen.[11] Another derivative of allenolic acid (specifically 6-methoxy-allenestrol), methallenestril (brand name Vallestril), is also a potent estrogen and, in contrast to allenolic acid and allenestrol, has been marketed.[12][13][14][15]
See also
[edit]References
[edit]- ^ Paoletti R, Pasetto N, Ambrus JL (6 December 2012). The Menopause and Postmenopause: The Proceedings of an International Symposium held in Rome, June 1979. Springer Science & Business Media. pp. 110–. ISBN 978-94-011-7230-1.
- ^ American Practitioner and Digest of Treatment. Lippincott. January 1951. p. 443.
- ^ Rea WJ, Patel K (18 June 2010). Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 1: Regulating Mechanisms of Chemical Sensitivity. CRC Press. pp. 464–. ISBN 978-1-4398-1345-4.
- ^ Geynet C, Millet C, Truong H, Baulieu EE (1972). "Estrogens and antiestrogens". Gynecologic Investigation. 3 (1): 2–29. doi:10.1159/000301742. PMID 4347198.
- ^ Furuya H, Deguchi K, Shima M (September 1957). "Experimental and clinical studies on a new synthetic estrogen, an allenolic acid derivative, vallestril". American Journal of Obstetrics and Gynecology. 74 (3): 635–50. doi:10.1016/0002-9378(57)90519-7. PMID 13458265.
- ^ Indian Journal of Chemistry: Organic including medicinal. Council of Scientific & Industrial Research. 1980. p. 886.
- ^ Ghalioungui P, Ghareeb A (1963). Endocrines, Vitamins, and Some Common Metabolic Disorders. Dar al-Maaref. p. 194.
- ^ Morrison JD (November 1983). Stereodifferentiating addition reactions. Academic Press. p. v. ISBN 978-0-12-507702-6.
- ^ Thompson WO (1953). The Year Book of Endocrinology. Year Book Medical Publishers. p. 292.
- ^ American Practitioner and Digest of Treatment. Lippincott. January 1956.
- ^ Clark ER, Robson RD (1959). "753. Oestrogenic carboxylic acids. Part II. Open-chain analogues of doisynolic acid". Journal of the Chemical Society (Resumed): 3714. doi:10.1039/jr9590003714. ISSN 0368-1769.
- ^ Journal of the Japanese Obstetrical & Gynecological Society. 1958. p. 83.
- ^ Heftmann E (1970). Steroid Biochemistry. Academic Press. p. 144. ISBN 9780123366504.
- ^ The Effects of the Sulfonylureas and Related Compounds in Experimental and Clinical Diabetes. The Academy. 1957. p. 681.
- ^ Sartorelli AC, Johns DG (27 November 2013). Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp. 106–. ISBN 978-3-642-65806-8.