CRYGA

CRYGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LER
Identifiers
Aliases	CRYGA, CRY-g-A, CRYG1, CRYG5, crystallin gamma A
External IDs	OMIM: 123660; MGI: 88521; HomoloGene: 129704; GeneCards: CRYGA; OMA:CRYGA - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	208,163,589 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	65,142,532 bp
RNA expression pattern
	Top expressed in
	testicle; ; Brodmann area 9; ; prefrontal cortex; ; nucleus accumbens; ; anterior cingulate cortex; ; right frontal lobe; ; primary visual cortex; ; putamen; ; superior frontal gyrus; ; amygdala;
	Top expressed in
	lens; ; blastocyst; ; embryo; ; right kidney; ; human kidney; ; striatum of neuraxis; ; hypothalamus; ; hippocampus proper; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of eye lens;
Cellular component	cellular component;
Biological process	eye development; visual perception; lens development in camera-type eye;
	Sources:Amigo / QuickGO
Orthologs
	1418
	12964
	ENSG00000168582
	ENSMUSG00000044429
	P11844
	P04345
	NM_014617
	NM_007774
	NP_055432
	NP_031800
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-crystallin A is a protein that in humans is encoded by the CRYGA gene.^[5]

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168582 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044429 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CRYGA crystallin, gamma A".

External links

Human CRYGA genome location and CRYGA gene details page in the UCSC Genome Browser.

Graw J (1998). "The crystallins: genes, proteins and diseases". Biol. Chem. 378 (11): 1331–48. doi:10.1515/bchm.1997.378.11.1299. PMID 9426193.
Slingsby C, Clout NJ (2000). "Structure of the crystallins". Eye. 13 ( Pt 3b) (3): 395–402. doi:10.1038/eye.1999.113. PMID 10627816.
Brakenhoff RH, Aarts HJ, Reek FH, et al. (1991). "Human gamma-crystallin genes. A gene family on its way to extinction". J. Mol. Biol. 216 (3): 519–32. doi:10.1016/0022-2836(90)90380-5. PMID 2258929.
den Dunnen JT, Jongbloed RJ, Geurts van Kessel AH, Schoenmakers JG (1985). "Human lens gamma-crystallin sequences are located in the p12-qter region of chromosome 2". Hum. Genet. 70 (3): 217–21. doi:10.1007/bf00273445. PMID 2991114. S2CID 23745896.
Shiloh Y, Donlon T, Bruns G, et al. (1986). "Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36". Hum. Genet. 73 (1): 17–9. doi:10.1007/BF00292656. PMID 3011643. S2CID 27997711.
Meakin SO, Du RP, Tsui LC, Breitman ML (1987). "Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family". Mol. Cell. Biol. 7 (8): 2671–9. doi:10.1128/mcb.7.8.2671. PMC 367883. PMID 3670288.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Santhiya ST, Shyam Manohar M, Rawlley D, et al. (2002). "Novel mutations in the γ-crystallin genes cause autosomal dominant congenital cataracts". J. Med. Genet. 39 (5): 352–8. doi:10.1136/jmg.39.5.352. PMC 1735119. PMID 12011157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Salim A, Zaidi ZH (2003). "Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins". Biochem. Biophys. Res. Commun. 300 (3): 624–30. doi:10.1016/S0006-291X(02)02895-4. PMID 12507494.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168582 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044429 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CRYGA crystallin, gamma A".

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[5]

CRYGA

References

External links

Further reading

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