Dequalinium

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Dequalinium

Clinical data
Trade names	Dequadin, Fluomizin, Vablys, others
Routes of administration	By mouth intravaginal
ATC code	D08AH01 (WHO) G01AC05 (WHO), R02AA02 (WHO)
Legal status
Legal status	CA: ℞-only[1] UK: POM (Prescription only)[2]
Identifiers
IUPAC name 1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride
CAS Number	6707-58-0
PubChem CID	2993
IUPHAR/BPS	2313
DrugBank	DB04209
ChemSpider	2886
UNII	E7QC7V26B8
ChEBI	CHEBI:31466
ChEMBL	ChEMBL333826 ChEMBL121663
CompTox Dashboard (EPA)	DTXSID3045144
ECHA InfoCard	100.007.575
Chemical and physical data
Formula	C30H40N4
Molar mass	456.678 g·mol−1
3D model (JSmol)	Interactive image
SMILES c12ccccc1c(cc([n+]2CCCCCCCCCC[n+]4c3ccccc3c(N)cc4C)C)N
InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 Key:PCSWXVJAIHCTMO-UHFFFAOYSA-P

Dequalinium is a quaternary ammonium cation and bolaamphiphile commonly available as the dichloride salt. It is useful as an antiseptic and disinfectant. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications.

The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by an N-decylene chain.

Dequalinium chloride 0.25 mg is available as an over-the-counter throat lozenge under brand names such as Dequadin and SP Troche. Mouthwash and buccal sprays at 0.5 % concentration are also available.^{[3][unreliable medical source?]} In this form is it used to treat minor infections of the mouth and throat. It can help with tonsillitis but is not effective in cases of streptococci infections.^[4]

The product is also available as a 10 mg prescription vaginal tablet for treating vaginal bacterial conditions (i.e. bacterial Vaginosis and aerobic vaginitis). Brand names include Fluomizin and Vablys.^[3]

In Austria, dequalinium chloride is combined with bacitracin and diphenylpyraline in Eucillin "B", an antibiotic cream. This cream is the first dequalinium-containing product to enter Austria in 1967.^[3]

Dequalinium salts have broad bactericidal and fungicidal activity.^[5] In OTC oral products containing a low concentration, the product is instead described as a bacteriostat.^{[citation needed]}

Dequalinium salts may have antimalarial activities.^[6]

Dequalinium may cause skin necrosis "if administered on intertriginous skin areas under occlusive conditions".^[6]

Dequalinium was first described by M Babbs and colleagues in 1956, as the first agent of the bisquaternary ammonium chemical class.^[7]

• Comparative Study of Efficacy of 10 mg Dequalinium Chloride (Fluomizin) in the Local Treatment of Bacterial Vaginosis

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