Protein-coding gene in the species Homo sapiens
Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene .[ 5] [ 6]
This gene encodes a member of the family of voltage-gated potassium (Kv ) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[ 7] N-terminus . They are integral subunit components of native Kv 4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000182132 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053519 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature . 403 (6769): 553–556. Bibcode :2000Natur.403..553A . doi :10.1038/35000592 . PMID 10676964 . S2CID 4419472 . ^ a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1" .^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling" . Nat. Rev. Neurosci . 8 (3): 182–193. doi :10.1038/nrn2093 . PMC 1887812 PMID 17311005 . Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating" . J. Biol. Chem . 276 (26): 23888–23894. doi :10.1074/jbc.M101320200 PMID 11287421 . Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2" . FEBS Lett . 499 (3): 205–209. Bibcode :2001FEBSL.499..205N . doi :10.1016/S0014-5793(01)02560-1 PMID 11423117 . S2CID 23908034 . Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome" . Nucleic Acids Res . 30 (14): 3163–3170. doi :10.1093/nar/gkf428 . PMC 135748 PMID 12136098 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels" . J. Biol. Chem . 278 (38): 36445–36454. doi :10.1074/jbc.M306142200 PMID 12829703 . Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants". Mol. Cell. Neurosci . 24 (2): 357–366. doi :10.1016/S1044-7431(03)00174-X . PMID 14572458 . S2CID 40647616 . Scannevin RH, Wang K, Jow F, et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1" . Neuron . 41 (4): 587–598. doi :10.1016/S0896-6273(04)00049-2 PMID 14980207 . S2CID 17380435 . Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun . 319 (3): 720–724. doi :10.1016/j.bbrc.2004.05.064 . PMID 15184042 . Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun . 321 (3): 606–610. doi :10.1016/j.bbrc.2004.07.006 . PMID 15358149 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics . 86 (5): 581–593. doi :10.1016/j.ygeno.2005.07.001 . PMID 16112838 . Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer" . Nat. Struct. Mol. Biol . 13 (11): 987–995. doi :10.1038/nsmb1164 . PMC 3018330 PMID 17057713 . {{cite journal }}: CS1 maint: multiple names: authors list (link )Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD (2005). "Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway" . J. Cell Biol . 171 (3): 459–469. doi :10.1083/jcb.200506005 . PMC 2171252 PMID 16260497 . Venn N, Haynes LP, Burgoyne RD (2008). "Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells" . Biochem. J . 413 (1): 71–80. doi :10.1042/BJ20080441 . PMC 2474559 PMID 18393943 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
PDB gallery
1s1e : Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)
1s6c : Crystal structure of the complex between KChIP1 and Kv4.2 N1-30
2i2r : Crystal structure of the KChIP1/Kv4.3 T1 complex
2nz0 : Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)
