Protein-coding gene in the species Homo sapiens
Kin of IRRE-like protein 3 (KIRREL3) also known as kin of irregular chiasm-like protein 3 or NEPH2 is a protein that in humans is encoded by the KIRREL3 gene .[ 5]
NEPH2 is a member of the NEPH protein family of transmembrane proteins , which includes NEPH1 (KIRREL ) and NEPH3 (KIRREL2 ). The NEPH proteins can interact with nephrin and CASK .
NEPH2 has been implicated in synapse formation.[ 6] brain function.[ 7]
NEPH1 and NEPH2 are involved in the blood filtration function of the kidney and are located in the slit diaphragm .[ 8]
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