Keratin 34

KRT34
Identifiers
Aliases	KRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34, K34
External IDs	OMIM: 602763; MGI: 1309994; HomoloGene: 31083; GeneCards: KRT34; OMA:KRT34 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,382,306 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,932,380 bp
RNA expression pattern
	Top expressed in
	testicle; ; stromal cell of endometrium; ; placenta; ; skin of abdomen; ; ectocervix; ; skin of leg; ; vagina; ; canal of the cervix; ; right lung; ; mucosa of esophagus;
	Top expressed in
	lip; ; skin of back; ; hair follicle; ; skin of abdomen; ; dermis; ; skin of external ear; ; sexually immature organism; ; conjunctival fornix; ; medial head of gastrocnemius muscle; ; foregut;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; extracellular exosome; extracellular space; cytosol;
Biological process	epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3885
	16672
	ENSG00000131737; ENSG00000262045
	ENSMUSG00000043485
	O76011
	Q9D646
	NM_021013; NM_001386014
	NM_027563
	NP_066293
	NP_081839
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.^[8]

References

^ ^a ^b ^c ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043485 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT34 keratin 34".

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635 (inactive 2024-04-03). PMID 7686952.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma". Romanian Journal of Morphology and Embryology. 46 (1): 11–5. PMID 16286979.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.

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