The following is a list of transfers for the 2022 Major League Soccer (MLS) season that have been made during the 2021–22 MLS offseason all the way through to the roster freeze.
List of 2022 MLS transfers | Date | Name | Moving from | Moving to | Mode of Transfer |
| October 12, 2021 |  Missael Rodríguez | Chicago Fire Academy | Chicago Fire FC | Homegrown player[1] |
| October 23, 2021 | Sergio Oregel | Chicago Fire Academy | Chicago Fire FC | Homegrown player[2] |
| December 5, 2021 |  Gabriele Corbo | Bologna | CF Montréal | Loan[3] |
| December 12, 2021 | Teal Bunbury | New England Revolution | Nashville SC | Trade[4] |
 Franco Escobar | Atlanta United FC | Los Angeles FC | Trade[5] |
| Jaylin Lindsey | Sporting Kansas City | Charlotte FC | Trade[6] |
 Lewis Morgan | Inter Miami CF | New York Red Bulls | Trade[7] |
 Jean Mota | Santos | Inter Miami CF | Transfer[8] |
 Pablo Sisniega | Los Angeles FC | Charlotte FC | Trade[9] |
| Daniel Steres | LA Galaxy | Houston Dynamo FC | Trade[10] |
| Ethan Zubak | LA Galaxy | Nashville SC | Trade[11] |
| December 13, 2021 |  Eduard Atuesta | Los Angeles FC | Palmeiras | Transfer[12] |
| Vinicius Mello | Internacional | Charlotte FC | Transfer[13] |
| December 14, 2021 | Samuel Adeniran | Tacoma Defiance | Seattle Sounders FC | Free[14] |
| Tristan Blackmon | Los Angeles FC | Charlotte FC | Expansion Draft[15] |
| Charlotte FC | Vancouver Whitecaps FC | Trade[15] |
| McKinze Gaines | Austin FC | Charlotte FC | Expansion Draft[15] |
 Joseph Mora | D.C. United | Charlotte FC | Expansion Draft[15] |
 Ismael Tajouri-Shradi | New York City FC | Charlotte FC | Expansion Draft[15] |
| Charlotte FC | Los Angeles FC | Trade[15] |
| Obed Vargas | Tacoma Defiance | Seattle Sounders FC | Homegrown player[14] |
 Anton Walkes | Atlanta United FC | Charlotte FC | Expansion Draft[15] |
| December 16, 2021 | Alec Kann | Atlanta United FC | FC Cincinnati | Free[16] |
| Ariel Lassiter | Houston Dynamo FC | Inter Miami CF | Trade[17] |
| Sebastian Lletget | LA Galaxy | New England Revolution | Trade[18] |
| Dylan Nealis | Nashville SC | New York Red Bulls | Trade[19] |
| December 17, 2021 | Mo Adams | Atlanta United FC | Inter Miami CF | Trade[20] |
 Harrison Afful | Columbus Crew | Charlotte FC | Free[21] |
| Josh Bauer | Atlanta United FC | Nashville SC | Re-Entry Draft Stage 1[22] |
| Dylan Castanheira | Inter Miami CF | Atlanta United FC | Trade[20] |
| Daniel Edelman | New York Red Bulls II | New York Red Bulls | Homegrown player[23] |
 Alvas Powell | Philadelphia Union | FC Cincinnati | Free[24] |
 Yordy Reyna | D.C. United | Charlotte FC | Free[25] |
| December 18, 2021 | Justin Portillo | Real Salt Lake | New Mexico United | Free[26] |
| December 20, 2021 | Ethan Finlay | Minnesota United FC | Austin FC | Free[27] |
| Spencer Richey | Seattle Sounders FC | Chicago Fire FC | Free[28] |
| Ben Sweat | Austin FC | Sporting Kansas City | Free[29] |
| December 21, 2021 |  Alan Franco | Atlético Mineiro | Charlotte FC | Loan[30] |
 Oriol Rosell | Orlando City SC | Sporting Kansas City | Free[31] |
| December 22, 2021 | Victor Bezerra | Indiana Hoosiers | Chicago Fire FC | Homegrown player[32] |
| Steve Clark | Portland Timbers | Houston Dynamo FC | Free[33] |
| Omar Gonzalez | Toronto FC | New England Revolution | Free[34] |
| Shane O'Neill | Seattle Sounders FC | Toronto FC | Free[35] |
| December 23, 2021 |  Bryan Acosta | FC Dallas | Colorado Rapids | Re-Entry Draft Stage 2[36] |
 Osvaldo Alonso | Minnesota United FC | Atlanta United FC | Free[37] |
 Robert Berić | Chicago Fire FC | Sporting Kansas City | Re-Entry Draft Stage 2[36] |
| Julián Carranza | Inter Miami CF | Philadelphia Union | Loan[38] |
| Eric Dick | Columbus Crew | Minnesota United FC | Re-Entry Draft Stage 2[36] |
| Jonathan dos Santos | LA Galaxy | Club América | Free[39] |
 Ján Greguš | Minnesota United FC | San Jose Earthquakes | Re-Entry Draft Stage 2[36] |
| John Nelson | FC Dallas | FC Cincinnati | Re-Entry Draft Stage 2[36] |
| Brady Scott | Austin FC | Columbus Crew | Re-Entry Draft Stage 2[36] |
| December 27, 2021 |  Alistair Johnston | Nashville SC | CF Montréal | Trade[40] |
| December 28, 2021 |  Kristijan Kahlina |  Ludogorets Razgrad | Charlotte FC | Transfer[41] |
| Kyle Morton | Houston Dynamo FC | Louisville City | Free[42] |
| Maximiliano Urruti | Houston Dynamo FC | Austin FC | Free[43] |
| January 1, 2022 | Jordy Alcívar | L.D.U. Quito | Charlotte FC | Transfer[44] |
| Ignacio Aliseda | Chicago Fire FC |  FC Lugano | Transfer[45] |
| Ventura Alvarado | Inter Miami CF | FC Juárez | Free |
| Carlos Miguel Coronel |  Red Bull Salzburg | New York Red Bulls | Transfer[46] |
 Guzmán Corujo | Nacional | Charlotte FC | Free[47] |
| Daryl Dike | Orlando City SC | West Bromwich Albion | Transfer[48] |
| Kyle Duncan | New York Red Bulls |  Oostende | Free[49] |
| Julian Dunn | Toronto FC |  HamKam | Free[50] |
| Jhon Durán | Envigado | Chicago Fire FC | Transfer[51] |
 Ahmed Hamdy | El Gouna | CF Montréal | Transfer[52] |
| Žan Kolmanič | Maribor | Austin FC | Transfer[53] |
 Lassi Lappalainen | Bologna | CF Montréal | Transfer[54] |
| Álvaro Medrán | Chicago Fire FC |  Al-Taawoun | Free[55] |
| Chris Mueller | Orlando City SC | Hibernian | Free[56] |
| Jukka Raitala | Minnesota United FC | HJK | Free[57] |
 Gaoussou Samaké | ASEC Mimosas | D.C. United | Transfer[58] |
| Joaquín Torres | Newell's Old Boys | CF Montréal | Transfer[59] |
| Gustavo Vallecilla | Aucas | FC Cincinnati | Transfer[60] |
| January 2, 2022 |  Rafael Czichos | FC Köln | Chicago Fire FC | Transfer[61] |
| January 3, 2022 | Ricardo Pepi | FC Dallas | FC Augsburg | Transfer[62] |
| January 4, 2022 |  Dominique Badji | Colorado Rapids | FC Cincinnati | Free[63] |
| Sean Davis | New York Red Bulls | Nashville SC | Free[64] |
| Bryce Duke | Los Angeles FC | Inter Miami CF | Trade[65] |
| Brendan Hines-Ike | K.V. Kortrijk | D.C. United | Transfer[66] |
| Rodolfo Pizarro | Inter Miami CF | Monterrey | Loan[67] |
| Aedan Stanley | Austin FC | Miami FC | Free[68] |
| January 5, 2022 |  Alejandro Fuenmayor | Houston Dynamo FC | Oakland Roots | Free[69] |
| Ray Gaddis | Retired | FC Cincinnati | Free[70] |
 Bongokuhle Hlongwane | Maritzburg United | Minnesota United FC | Transfer[71] |
| Aboubacar Keita | Columbus Crew | Colorado Rapids | Trade[72] |
| James Sands | New York City FC | Rangers | Loan[73] |
| Caleb Stanko | FC Cincinnati |  PAS Giannina | Free[74] |
| January 6, 2022 | Max Alves | Flamengo | Colorado Rapids | Transfer[75] |
| Chris Hegardt | Georgetown Hoyas | Charlotte FC | Homegrown player[76] |
 Kelvin Leerdam | Inter Miami CF | LA Galaxy | Free[77] |
| Emmanuel Mas | Orlando City SC | Estudiantes | Free[78] |
| Yaw Yeboah |  Wisła Kraków | Columbus Crew | Transfer[79] |
| January 7, 2022 | Danilo Acosta | LA Galaxy | Orange County SC | Free[80] |
| César Araújo | Montevideo Wanderers | Orlando City SC | Transfer[81] |
 Elliot Collier | Chicago Fire FC | San Antonio FC | Free[82] |
| Raheem Edwards | Los Angeles FC | LA Galaxy | Free[83] |
| January 8, 2022 | Richie Laryea | Toronto FC | Nottingham Forest | Transfer[84] |
 Erik Sorga | D.C. United |  IFK Göteborg | Transfer[85] |
| January 9, 2022 | Sebastian Breza | Bologna | CF Montréal | Loan[86] |
| January 10, 2022 |  José Bizama | Houston Dynamo FC | Palestino | Free[87] |
| Dom Dwyer | Toronto FC | FC Dallas | Trade[88] |
| Justin Garces | UCLA Bruins | Atlanta United FC | Homegrown player[89] |
| Leandro González Pírez | Inter Miami CF | River Plate | Loan[90] |
| Christian Makoun | Charlotte FC | Trade[91] |
 Nanu |  Porto | FC Dallas | Loan[92] |
| Tomás Pochettino | Austin FC | River Plate | Loan[93] |
| January 11, 2022 | Ben Bender | Maryland Terrapins | Charlotte FC | SuperDraft[94] |
 Ousseni Bouda | Stanford Cardinal | San Jose Earthquakes |
| Roman Celentano | Indiana Hoosiers | FC Cincinnati |
| Erik Centeno | Pacific Tigers | Atlanta United FC |
| Clément Diop | CF Montréal | Inter Miami CF | Free[95] |
| Tega Ikoba | North Carolina Tar Heels | Portland Timbers | Homegrown player[96] |
| Kipp Keller | Saint Louis Billikens | Austin FC | SuperDraft[94] |
| David Loera | Orlando City SC | San Antonio FC | Free[97] |
| Isaiah Parker | Saint Louis Billikens | FC Dallas | SuperDraft[94] |
| Luca Petrasso | Toronto FC II | Toronto FC | Homegrown player[98] |
| Will Richmond | Stanford Cardinal | San Jose Earthquakes | Homegrown player[99] |
| Patrick Schulte | Saint Louis Billikens | Columbus Crew | SuperDraft[94] |
| Dylan Teves | Washington Huskies | Seattle Sounders FC | Homegrown player[100] |
 Thorleifur Úlfarsson | Duke Blue Devils | Houston Dynamo FC | SuperDraft[94] |
| Jude Wellings | Real Salt Lake Academy | Real Salt Lake | Homegrown player[101] |
| January 12, 2022 | Julio Benitez | Real Monarchs | Homegrown player[102] |
| Scott Caldwell | New England Revolution | Free[103] |
| Jay Chapman | Inter Miami CF | Dundee | Free[104] |
| Ilie Sánchez | Sporting Kansas City | Los Angeles FC | Free[105] |
| January 13, 2022 | Raul Aguilera | Orlando City SC | Indy Eleven | Free[106] |
| Gavin Beavers | Real Monarchs | Real Salt Lake | Homegrown player[107] |
| David Bingham | Unattached | Portland Timbers | Free[108] |
| Abu Danladi | Nashville SC | Minnesota United FC | Free[109] |
| Ted Ku-DiPietro | Loudoun United | D.C. United | Homegrown player[110] |
| Matt LaGrassa | Nashville SC | Sacramento Republic | Free[111] |
 Aimé Mabika | Fort Lauderdale CF | Inter Miami CF | Free[112] |
| Jaziel Orozco | Real Monarchs | Real Salt Lake | Homegrown player[113] |
| Albert Rusnák | Real Salt Lake | Seattle Sounders FC | Free[114] |
| Erick Torres | Atlanta United FC | Orange County SC | Free [115] |
| Jhojan Valencia | Deportivo Cali | Austin FC | Transfer[116] |
 Florian Valot | FC Cincinnati | Miami FC | Free[117] |
| Sean Zawadzki | Georgetown Hoyas | Columbus Crew | Homegrown player[118] |
| January 14, 2022 | Kellyn Acosta | Colorado Rapids | Los Angeles FC | Trade[119] |
| Jalil Anibaba | Nashville SC | Columbus Crew | Free[120] |
| Amadou Dia | Sporting Kansas City | Louisville City | Free[121] |
| Kortne Ford | Colorado Rapids | Sporting Kansas City | Free[122] |
| Axel Kei | Real Monarchs | Real Salt Lake | Homegrown player[123] |
 Riley McGree | Charlotte FC | Middlesbrough | Transfer[124] |
| Christopher McVey | Elfsborg | Inter Miami CF | Transfer[125] |
| Jake Morris | Campbell Fighting Camels | Columbus Crew | Homegrown player[126] |
| Nani | Orlando City SC | Venezia | Free[127] |
| Logan Ndenbe | Guingamp | Sporting Kansas City | Transfer[128] |
 Noah Powder | Real Salt Lake | Indy Eleven | Free[129] |
| Bobby Shuttleworth | Chicago Fire FC | Atlanta United FC | Free[130] |
| Niko Tsakiris | Quakes Academy | San Jose Earthquakes | Homegrown player[131] |
| January 15, 2022 | Rodrigo Piñeiro | Nashville SC | Unión Española | Loan[132] |
 Vito Wormgoor | Columbus Crew | Start | Free[133] |
| January 16, 2022 | Damion Lowe | Al Ittihad | Inter Miami CF | Free[134] |
| Adrian Zendejas | Minnesota United FC | Charlotte FC | Free[135] |
| January 17, 2022 | Ronald Hernández | Aberdeen | Atlanta United FC | Transfer[136] |
 Jesús Medina | New York City FC |  CSKA Moscow | Free[137] |
| January 18, 2022 | Noel Buck | New England Revolution II | New England Revolution | Homegrown player[138] |
| Toni Datković | Real Salt Lake | Cartagena | Transfer[139] |
| Sebastián Ferreira | Club Libertad | Houston Dynamo | Transfer[140] |
| Liam Fraser | Toronto FC | KMSK Deinze | Free[141] |
| Richard Sánchez | North Texas SC | LA Galaxy | Free[142] |
| Caleb Wiley | Atlanta United 2 | Atlanta United FC | Homegrown player[143] |
| January 19, 2022 | Nicholas Benalcazar | Wake Forest Demon Deacons | New York City FC | Homegrown player[144] |
| Jonathan Jimenez | North Carolina Tar Heels | Homegrown player[144] |
| Cristian Ortíz | Tijuana | Charlotte FC | Loan[145] |
| Samuel Kwaku Owusu | NYCFC Academy | New York City FC | Homegrown player[144] |
| Emerson Rodriguez | Millonarios | Inter Miami CF | Transfer[146] |
| Robert Voloder | Maribor | Sporting Kansas City | Transfer[147] |
| January 20, 2022 | Cole Bassett | Colorado Rapids | Feyenoord | Loan[148] |
| Leonardo Campana | Wolverhampton | Inter Miami CF | Loan[149] |
| Jesús Castellano | Yaracuyanos | New York Red Bulls | Transfer[150] |
| Maxime Crépeau | Vancouver Whitecaps FC | Los Angeles FC | Trade[151] |
| Jake LaCava | New York Red Bulls II | New York Red Bulls | Free[152] |
| New York Red Bulls | Tampa Bay Rowdies | Loan[152] |
| Maarten Paes | Utrecht | FC Dallas | Loan[153] |
| Zach Ryan | Stanford Cardinal | New York Red Bulls | Homegrown player[154] |
| Patrick Seagrist | Inter Miami CF | Memphis 901 | Free[155] |
| Diego Valeri | Portland Timbers | Lanús | Transfer[156] |
| January 21, 2022 | Janio Bikel | Vancouver Whitecaps FC | L.R. Vicenza | Loan[157] |
| Justin Che | FC Dallas | TSG 1899 Hoffenheim | Loan[158] |
| Mark Delgado | Toronto FC | LA Galaxy | Trade[159] |
| Deandre Kerr | Syracuse Orange | Toronto FC | Homegrown player[160] |
| John McCarthy | Inter Miami CF | Los Angeles FC | Free[161] |
| Greg Ranjitsingh | MLS Pool | Toronto FC | Free[162] |
| Will Sands | Georgetown Hoyas | Columbus Crew | Homegrown player[163] |
| January 22, 2022 | Kacper Przybyłko | Philadelphia Union | Chicago Fire FC | Trade[164] |
| January 24, 2022 | Miloš Degenek |  Red Star Belgrade | Columbus Crew | Free[165] |
| Nicolás Figal | Inter Miami CF | Boca Juniors | Transfer[166] |
| Ruben Gabrielsen | Toulouse | Austin FC | Transfer[167] |
| Ben Lundt | FC Cincinnati | Phoenix Rising | Free[168] |
| Hayden Sargis | Sacramento Republic | D.C. United | Free[169] |
| Facundo Torres | Peñarol | Orlando City SC | Transfer[170] |
 Marinos Tzionis | Omonia | Sporting Kansas City | Transfer[171] |
| January 25, 2022 | Damian Las | Fulham | Austin FC | Transfer[172] |
| Lukas MacNaughton | Pacific FC | Toronto FC | Free[173] |
| Evan Newton | Vancouver Whitecaps FC | El Paso Locomotive | Loan[174] |
| Anthony Sorenson | Philadelphia Union II | Philadelphia Union | Homegrown player[175] |
| Luka Stojanović | Chicago Fire FC | Al-Hazem | Free[176] |
| January 26, 2022 | Alexander Alvarado | Orlando City SC | L.D.U. Quito | Loan[177] |
| Paul Arriola | D.C. United | FC Dallas | Trade[178] |
| Francisco Calvo | Chicago Fire FC | San Jose Earthquakes | Free[179] |
 James Igbekeme | Real Zaragoza | Columbus Crew | Loan[180] |
 Mathias Jørgensen | New York Red Bulls | Esbjerg | Free[181] |
| Karol Świderski | PAOK | Charlotte FC | Transfer[182] |
| Justin Vom Steeg | LA Galaxy | Portland Timbers | Free[183] |
| January 27, 2022 | Ercan Kara | Rapid Vienna | Orlando City SC | Transfer[184] |
 Douglas Martínez | Real Salt Lake | Sacramento Republic | Free[185] |
| Brad Smith | Seattle Sounders FC | D.C. United | Trade[186] |
| Mikael Uhre | Brøndby | Philadelphia Union | Transfer[187] |
| January 28, 2022 | Mateo Bajamich | Houston Dynamo | CA Huracán | Loan[188] |
| Lucas Bartlett | St. John's Red Storm | FC Dallas | SuperDraft[189] |
| Sami Guediri | Inter Miami CF | Loudoun United | Free[190] |
| Grant Lillard | Columbus Crew | Free[190] |
| Trey Muse | Seattle Sounders FC | Free[190] |
| Kevin Paredes | D.C. United | VfL Wolfsburg | Transfer[191] |
| January 29, 2022 | Esequiel Barco | Atlanta United FC | River Plate | Loan[192] |
| January 30, 2022 | Milton Valenzuela | Columbus Crew | Lugano | Free[193] |
| January 31, 2022 | Theo Bair | Vancouver Whitecaps FC | St Johnstone | Transfer[194] |
| George Bello | Atlanta United FC | Arminia Bielefeld | Transfer[195] |
| Jamal Blackman | Los Angeles FC | Huddersfield Town | Free[196] |
| Carlos Salcedo | Tigres | Toronto FC | Transfer[197] |
| Yeferson Soteldo | Toronto FC | Tigres | Transfer[198] |
| Auston Trusty | Colorado Rapids | Arsenal | Transfer[199] |
| Arsenal | Colorado Rapids | Loan[199] |
| February 1, 2022 | David Ayala | Estudiantes | Portland Timbers | Transfer[200] |
 Tsubasa Endoh | Toronto FC | Melbourne City | Free[201] |
| Ashtone Morgan | Real Salt Lake | Forge FC | Free[202] |
 Selmir Pidro | Sarajevo | St. Louis City SC | Transfer[203] |
| Alan Velasco | Independiente | FC Dallas | Transfer[204] |
| February 2, 2022 | Yamil Asad | D.C. United | Universidad Católica | Free[205] |
| Oniel Fisher | LA Galaxy | Minnesota United FC | Free[206] |
| Marko Marić | Houston Dynamo | Atromitos | Free[207] |
| DeAndre Yedlin |  Galatasaray | Inter Miami CF | Free[208] |
| February 3, 2022 | Sergio Córdova | FC Augsburg | Real Salt Lake | Loan[209] |
| Wilson Harris | Sporting Kansas City | Louisville City | Free[210] |
| February 4, 2022 | Sebastian Berhalter | Columbus Crew | Vancouver Whitecaps FC | Trade[211] |
| Brooklyn Raines | El Paso Locomotive | Houston Dynamo FC | Homegrown player[212] |
| February 5, 2022 | Ethan Dobbelaere | Seattle Sounders FC |  MFK Vyškov | Loan[213] |
| February 7, 2022 | Felipe | D.C. United | Austin FC | Free[214] |
| Jesús Jiménez | Górnik Zabrze | Toronto FC | Transfer[215] |
 Kekuta Manneh | Austin FC | San Antonio FC | Free[216] |
| Thiago Martins | Yokohama F. Marinos | New York City FC | Transfer[217] |
| February 8, 2022 | Michael Estrada | Toluca | D.C. United | Loan[218] |
| Josecarlos Van Rankin | Chivas | Portland Timbers | Loan[219] |
| February 9, 2022 | Thiago Almada | Vélez Sarsfield | Atlanta United FC | Transfer[220] |
| Caden Clark | RB Leipzig | New York Red Bulls | Loan[221] |
| Xherdan Shaqiri | Lyon | Chicago Fire FC | Transfer[222] |
| February 10, 2022 | Douglas Costa | Juventus | LA Galaxy | Loan[223] |
| Marco Farfan | Los Angeles FC | FC Dallas | Trade[224] |
| Ryan Hollingshead | FC Dallas | Los Angeles FC |
| Zeca | Vasco da Gama | Houston Dynamo | Free[225] |
| February 11, 2022 | CJ dos Santos | Benfica B | Inter Miami CF | Transfer[226] |
| Tsiki Ntsabeleng | Oregon State Beavers | FC Dallas | SuperDraft[227] |
| Robert Taylor | Brann | Inter Miami CF | Transfer[228] |
| February 14, 2022 | Jozy Altidore | Toronto FC | New England Revolution | Free[229] |
| Auro Jr. | Santos | Loan[230] |
 Jamiro Monteiro | Philadelphia Union | San Jose Earthquakes | Trade[231] |
| Roberto Punčec | Sporting Kansas City | Botev Plovdiv | Free[232] |
| Jackson Ragen | Tacoma Defiance | Seattle Sounders FC | Free[233] |
| February 15, 2022 | Alex Freeman | Orlando City U17 | Orlando City SC | Homegrown player[234] |
| Jacob Jackson | Loyola Marymount Lions | New England Revolution | SuperDraft[235] |
 Nikola Vujnović | Voždovac | Sporting Kansas City | Loan[236] |
| February 16, 2022 | Kervin Arriaga | Marathón | Minnesota United FC | Transfer[237] |
| Luquinhas | Legia Warsaw | New York Red Bulls | Transfer[238] |
| Jack Lynn | Notre Dame Fighting Irish | Orlando City SC | SuperDraft[239] |
| Logan Ketterer | El Paso Locomotive | CF Montréal | Free[240] |
| February 17, 2022 | Tom Edwards | Stoke City | New York Red Bulls | Loan[241] |
| Joe Gyau | FC Cincinnati | Degerfors IF | Free[242] |
| Serge Ngoma | New York Red Bulls II | New York Red Bulls | Free[243] |
| Justin Rasmussen | Grand Canyon Antelopes | Portland Timbers | SuperDraft[244] |
| February 18, 2022 | Oskar Ågren | Clemson Tigers | San Jose Earthquakes[245] |
| Doneil Henry |  Suwon Bluewings | Los Angeles FC | Free[246] |
 Kei Kamara | HIFK | CF Montréal | Free[247] |
| Johan Kappelhof | Chicago Fire FC | Real Salt Lake | Free[248] |
 Tony Rocha | New York City FC | Orange County SC | Free[249] |
| Ryan Spaulding | New England Revolution II | New England Revolution | Free[250] |
| February 19, 2022 | Luis Amarilla | Vélez Sarsfield | Minnesota United FC | Transfer[251] |
| Jairo Torres | Atlas | Chicago Fire FC | Transfer[252] |
| February 21, 2022 | Antonio Carrera | North Texas SC | FC Dallas | Free[253] |
| February 22, 2022 | Dom Dwyer | FC Dallas | Atlanta United FC | Free[254] |
| Erik López | Atlanta United FC | Banfield | Loan[255] |
| Koa Santos | San Diego State Aztecs | Charlotte FC | Free[256] |
| February 23, 2022 | Charlie Asensio | Clemson Tigers | Austin FC | SuperDraft[257] |
| Kadin Chung | Pacific FC | Toronto FC | Free[258] |
| Nick Markanich | Northern Illinois Huskies | FC Cincinnati | SuperDraft[259] |
| Ian Murphy | Duke Blue Devils |
| February 25, 2022 | Kendall Burks | Washington Huskies | Chicago Fire FC | SuperDraft[260] |
| Sofiane Djeffal | Oregon State Beavers | D.C. United | SuperDraft[261] |
| Diego Gutierrez | Creighton Bluejays | Portland Timbers | SuperDraft[262] |
| Júnior Moreno | D.C. United | FC Cincinnati | Trade[263] |
| Tani Oluwaseyi | St. John's Red Storm | Minnesota United FC | SuperDraft[264] |
| Daniel Ríos | Nashville SC | Charlotte FC | Trade[265] |
| Harrison Robledo | FC Cincinnati Academy | FC Cincinnati | Homegrown player[266] |
| Kosi Thompson | Toronto FC II | Toronto FC | Homegrown player[267] |
| Jürgen Damm | Atlanta United FC | Unattached | Buyout[268] |
| February 27, 2022 | Jasper Löeffelsend | Pittsburgh Panthers | Real Salt Lake | SuperDraft[269] |
 Xavier Valdez | Houston Dynamo Academy | Houston Dynamo FC | Homegrown player[270] |
| February 28, 2022 | Maximo Carrizo | New York City FC Academy | New York City FC | Homegrown player[271] |
| Ashley Fletcher | Watford | New York Red Bulls | Loan[272] |
| March 1, 2022 | Matt Hundley | Colorado Rapids | Unattached | Free[273] |
| March 3, 2022 | Anthony Markanich | Northern Illinois Huskies | Colorado Rapids | SuperDraft[274] |
| Joshué Quiñónez | Barcelona SC | FC Dallas | Loan[275] |
| Luke Singh | Toronto FC | FC Edmonton | Loan[276] |
| March 4, 2022 | Jackson Travis | Colorado Rapids Academy | Colorado Rapids | Homegrown Player[277] |
| March 7, 2022 | Kevin O'Toole | Princeton Tigers | New York City FC | SuperDraft[278] |
| March 9, 2022 | Derrick Jones | Houston Dynamo | Charlotte FC | Trade[279] |
| March 10, 2022 | Kamil Jóźwiak | Derby County | Charlotte FC | Transfer[280] |
| Devin Padelford | Minnesota United Academy | Minnesota United FC | Homegrown player[281] |
 Eriq Zavaleta | Toronto FC | LA Galaxy | Free[282] |
| March 11, 2022 | Noah Allen | Inter Miami II | Inter Miami CF | Homegrown player[283] |
| Kamron Habibullah | Vancouver Whitecaps FC | Pacific FC | Loan[284] |
| March 12, 2022 | Freddy Kleemann | Austin FC | Birmingham Legion FC | Loan[285] |
| Will Pulisic | North Carolina FC | Loan[286] |
| Jonathan Sirois | CF Montréal | Valour FC | Loan[287] |
| March 15, 2022 | Cody Cropper | FC Cincinnati | Vancouver Whitecaps FC | Free[288] |
| March 17, 2022 | Kemar Lawrence | Toronto FC | Minnesota United FC | Trade[289] |
| Gabriel Pereira | Corinthians | New York City FC | Transfer[290] |
| March 18, 2022 | Kim Moon-hwan | Los Angeles FC | Jeonbuk Hyundai Motors | Transfer[291] |
| March 21, 2022 | Ronaldo Cisneros | Chivas Guadalajara | Atlanta United FC | Loan[292] |
| Taxiarchis Fountas | Rapid Vienna | D.C. United | Transfer[293] |
| Thiago | Flamengo | Houston Dynamo FC | Loan[294] |
| March 24, 2022 | Chris Durkin | Sint-Truiden | D.C. United | Transfer[295] |
| Omar Sowe | New York Red Bulls | Breiðablik | Loan[296] |
| March 28, 2022 | Gustavo Vallecilla | FC Cincinnati | Colorado Rapids | Transfer[297] |
| March 29, 2022 | Joe Corona | Houston Dynamo FC | GIF Sundsvall | Loan[298] |
| April 4, 2022 | Preston Judd | LA Galaxy II | LA Galaxy | Free[299] |
| April 5, 2022 |  Quinn McNeill | Clemson Tigers | Charlotte FC | Transfer[300] |
| Charlotte FC | Charlotte Independence | Loan[300] |
| April 6, 2022 | Djordje Petrović | Čukarički | New England Revolution | Transfer[301] |
| April 8, 2022 |  Jojea Kwizera | Utah Valley Wolverines | CF Montréal | SuperDraft[302] |
| April 13, 2022 | Obinna Nwobodo | Göztepe S.K. | FC Cincinnati | Transfer[303] |
| Jackson Hopkins | Loudoun United | D.C. United | Homegrown Player[304] |
| April 22, 2022 | Gyasi Zardes | Columbus Crew | Colorado Rapids | Trade[305] |
| April 25, 2022 | Nathan Ordaz | LAFC Academy | Los Angeles FC | Homegrown player[306] |
| April 27, 2022 | Rocco Ríos Novo | Lanús | Atlanta United FC | Loan[307] |
| Rafael Romo | OH Leuven | D.C. United | Transfer[308] |
| April 28, 2022 | Andrés Cubas | Nîmes | Vancouver Whitecaps FC | Free[309] |
| Anderson Julio | Atlético San Luis | Real Salt Lake | Transfer[310] |
| May 2, 2022 | Kerwin Vargas | CD Feirense | Charlotte FC | Transfer[311] |
| May 3, 2022 | Andre Shinyashiki | Colorado Rapids | Charlotte FC | Trade[312] |
| May 4, 2022 | Chase Gasper | Minnesota United FC | LA Galaxy | Trade[313] |
| Chris Kablan | SK Beveren | Real Salt Lake | Loan[314] |
| Luís Martins | Sporting Kansas City | Vancouver Whitecaps FC | Free[315] |
| Thomas Roberts | Austria Klagenfurt | FC Dallas | Loan Return[316] |
| Jefferson Savarino | Atlético Mineiro | Real Salt Lake | Transfer[317] |
| May 5, 2022 | Nathan Fogaça | Coritiba | Portland Timbers | Transfer[318] |
| Gastón González | Unión Santa Fe | Orlando City SC | Transfer[319] |
| Jake Mulraney | Atlanta United FC | Orlando City SC | Trade[320] |
| Chris Mueller | Hibernian F.C. | Chicago Fire FC | Free[321] |
| Indiana Vassilev | Aston Villa | Inter Miami CF | Loan[322] |
| May 6, 2022 | Beto Avila | Houston Dynamo 2 | Hpuston Dynamo | Free[323] |
| May 10, 2022 |  Adalberto Carrasquilla | FC Cartagena | Houston Dynamo FC | Transfer[324] |
| May 12, 2022 | Justin Reynolds | Chicago Fire Academy | Chicago Fire FC | Homegrown Player[325] |
| May 23, 2022 | Esmir Bajraktarevic | New England Revolution II | New England Revolution | Homegrown player[326] |
| June 1, 2022 | Ben Reveno | Free[327] |
| June 3, 2022 | Diego Luna | El Paso Locomotive | Real Salt Lake | Transfer[328] |
| Cruz Medina | San Jose Earthquakes Academy | San Jose Earthquakes | Homegrown player[329] |
| June 18, 2022 | Chris Donovan | Philadelphia Union II | Philadelphia Union | Free[330] |
| June 23, 2022 | Edison Flores | D.C. United | Atlas | Transfer[331] |
| June 27, 2022 | Alan Franco | Charlotte FC | Talleres | Loan[332] |
| June 28, 2022 | Nicolás Mezquida | Colorado Rapids | Volos | Transfer[333] |
| Maarten Paes | FC Utrecht | FC Dallas | Transfer[334] |
| June 29, 2022 | Jacen Russell-Rowe | Columbus Crew 2 | Columbus Crew | Homegrown player[335] |
| July 1, 2022 | Douglas Costa | Juventus | LA Galaxy | Free[223] |
| Giorgio Chiellini | Juventus | Los Angeles FC | Free[336] |
| Hector Herrera | Atlético Madrid | Houston Dynamo FC | Free[337] |
| Adrien Hunou | Minnesota United FC | Angers | Transfer[338] |
| Lorenzo Insigne | Napoli | Toronto FC | Free[339] |
| Matt Turner | New England Revolution |
|
