Name[ 2] Location Area[ 2] Designated Description Image Ash Meadows National Wildlife Refuge Nevada 36°25′N 116°20′W / 36.417°N 116.333°W / 36.417; -116.333 (Ash Meadows National Wildlife Refuge ) 36.71 sq mi 18 December 1986 Bolinas Lagoon California 37°55′N 122°41′W / 37.917°N 122.683°W / 37.917; -122.683 (Bolinas Lagoon ) 1.72 sq mi 1 September 1998 A tidal estuary located on the Pacific Flyway , the lagoon provides habitat for migratory birds as well as ducks, geese, and shorebirds. Cache -Lower White Rivers Arkansas 34°40′N 91°11′W / 34.667°N 91.183°W / 34.667; -91.183 (Cache-Lower White Rivers ) 314.19 sq mi 21 November 1989 Cache River-Cypress Creek Wetlands Illinois 37°13′N 89°8′W / 37.217°N 89.133°W / 37.217; -89.133 (Cache River-Cypress Creek Wetlands ) 93.75 sq mi 1 November 1994 Caddo Lake Texas , Louisiana 32°45′N 94°8′W / 32.750°N 94.133°W / 32.750; -94.133 (Caddo Lake ) 30.80 sq mi 23 October 1993 Catahoula Lake Louisiana 31°30′N 92°6′W / 31.500°N 92.100°W / 31.500; -92.100 (Catahoula Lake ) 46.9 sq mi 18 June 1991 Chesapeake Bay Estuarine Complex Maryland , Virginia 38°0′N 76°20′W / 38.000°N 76.333°W / 38.000; -76.333 (Chesapeake Bay Estuarine Complex ) 170 sq mi 4 June 1987 Cheyenne Bottoms Kansas 38°29′N 98°40′W / 38.483°N 98.667°W / 38.483; -98.667 (Cheyenne Bottoms ) 42.39 sq mi 19 October 1988 Chiwaukee Illinois Beach Lake Plain Illinois Wisconsin 42°25′02″N 87°48′42″W / 42.41722°N 87.81167°W / 42.41722; -87.81167 (Chiwaukee Prairie Illinois Beach Lake Plain ) 6.12 sq mi 6 October 2015 Bi-state, lake-coast lands, including Chiwaukee Prairie and Illinois Beach State Park Congaree National Park South Carolina 33°47′22″N 80°45′34″W / 33.78944°N 80.75944°W / 33.78944; -80.75944 (Congaree National Park ) 40.69 sq mi 2 February 2012 Connecticut River Estuary and Tidal Wetlands Complex Connecticut 41°15′N 72°18′W / 41.250°N 72.300°W / 41.250; -72.300 (Connecticut River Estuary and Tidal Wetlands Complex ) 25.03 sq mi 14 October 1994 Corkscrew Swamp Sanctuary Florida 26°24′N 81°31′W / 26.400°N 81.517°W / 26.400; -81.517 (Corkscrew Swamp Sanctuary ) 20.31 sq mi 23 March 2009 Delaware Bay Estuary Delaware , New Jersey 39°11′N 75°14′W / 39.183°N 75.233°W / 39.183; -75.233 (Delaware Bay Estuary ) 197.89 sq mi 20 May 1992 Door Peninsula Coastal Wetlands Wisconsin 45°13′20″N 85°00′00″W / 45.22222°N 85.00000°W / 45.22222; -85.00000 17.880 sq mi 6 October 2014 Edwin B. Forsythe National Wildlife Refuge New Jersey 39°36′N 74°17′W / 39.600°N 74.283°W / 39.600; -74.283 (Edwin B. Forsythe National Wildlife Refuge ) 50.5 sq mi 18 December 1986 Elkhorn Slough California 36°49′33″N 121°45′25″W / 36.8259°N 121.7569°W / 36.8259; -121.7569 (Elkhorn Slough ) 2.80 sq mi 25 June 2018 Everglades National Park Florida 25°33′N 80°55′W / 25.550°N 80.917°W / 25.550; -80.917 (Everglades National Park ) 2,357.14 sq mi 4 June 1987 Francis Beidler Forest South Carolina 33°15′N 80°22′W / 33.250°N 80.367°W / 33.250; -80.367 (Francis Beidler Forest ) 24.86 sq mi 30 May 2008 Grassland Ecological Area California 37°10′N 120°50′W / 37.167°N 120.833°W / 37.167; -120.833 (Grassland Ecological Area ) 250 sq mi 2 February 2005 Horicon Marsh Wisconsin 43°30′N 88°38′W / 43.500°N 88.633°W / 43.500; -88.633 (Horicon Marsh ) 49.85 sq mi 4 December 1990 Humbug Marsh Michigan 42°6′N 83°11′W / 42.100°N 83.183°W / 42.100; -83.183 (Humbug Marsh ) 0.73 sq mi 20 January 2010 Izembek Lagoon National Wildlife Refuge Alaska 55°45′N 162°41′W / 55.750°N 162.683°W / 55.750; -162.683 (Izembek Lagoon National Wildlife Refuge ) 650.32 sq mi 18 December 1986 Kakagon and Bad River Sloughs Wisconsin 46°39′N 90°41′W / 46.650°N 90.683°W / 46.650; -90.683 (Kakagon and Bad River Sloughs ) 16.81 sq mi 2 February 2012 Kawainui and Hamakua Marsh Complex Hawaii 21°24′N 157°45′W / 21.400°N 157.750°W / 21.400; -157.750 (Kawainui and Hamakua Marsh Complex ) 1.60 sq mi 2 February 2005 Laguna de Santa Rosa Wetland Complex California 38°24′N 122°47′W / 38.400°N 122.783°W / 38.400; -122.783 (Laguna de Santa Rosa Wetland Complex ) 6.08 sq mi 16 April 2010 Lower Wisconsin Riverway Wisconsin 43°09′N 90°21′W / 43.150°N 90.350°W / 43.150; -90.350 (Lower Wisconsin Riverway ) 68 sq mi 14 February 2020 Niagara River Corridor New York 43°5′N 79°4′W / 43.083°N 79.067°W / 43.083; -79.067 (Niagara River Corridor ) 20.261 sq mi 3 October 2019 Okefenokee National Wildlife Refuge Georgia , Florida 30°48′N 82°20′W / 30.800°N 82.333°W / 30.800; -82.333 (Okefenokee National Wildlife Refuge ) 627.94 sq mi 18 December 1986 Palmyra Atoll National Wildlife Refuge Line Islands 5°52′N 162°6′W / 5.867°N 162.100°W / 5.867; -162.100 (Palmyra Atoll National Wildlife Refuge ) 788.14 sq mi 1 April 2011 Pelican Island National Wildlife Refuge Florida 27°48′N 80°25′W / 27.800°N 80.417°W / 27.800; -80.417 (Pelican Island National Wildlife Refuge ) 7.37 sq mi 14 March 1993 Quivira National Wildlife Refuge Kansas 38°5′N 98°29′W / 38.083°N 98.483°W / 38.083; -98.483 (Quivira National Wildlife Refuge ) 34.59 sq mi 12 February 2002 The refuge has 34 wetlands and includes two shallow lakes, Big Salt Marsh and Little Salt Marsh. More than half of the refuge is Tallgrass and Shortgrass prairies . Roswell Artesian Wetlands New Mexico 33°27′N 104°23′W / 33.450°N 104.383°W / 33.450; -104.383 (Roswell Artesian Wetlands ) 3.54 sq mi 7 September 2010 San Francisco Bay and Estuary California 37°52′N 122°23′W / 37.867°N 122.383°W / 37.867; -122.383 (San Francisco Bay and Estuary ) 612.79 sq mi 2 February 2013 Sand Lake National Wildlife Refuge South Dakota 45°45′N 98°15′W / 45.750°N 98.250°W / 45.750; -98.250 (Sand Lake National Wildlife Refuge ) 34 sq mi 3 August 1998 Sue and Wes Dixon Waterfowl Refuge at Hennepin and Hopper Lake Illinois 41°13′20″N 89°20′17″W / 41.22222°N 89.33806°W / 41.22222; -89.33806 (Dixon Waterfowl Refuge ) 4.31 sq mi 2 February 2012 The Emiquon Complex Illinois 40°21′22″N 90°3′10″W / 40.35611°N 90.05278°W / 40.35611; -90.05278 (The Emiquon Complex ) 22.12 sq mi 2 February 2012 Tijuana River National Estuarine Research Reserve California 32°33′N 117°7′W / 32.550°N 117.117°W / 32.550; -117.117 (Tijuana River National Estuarine Research Reserve ) 3.94 sq mi 2 February 2005 Tomales Bay California 38°9′N 123°23′W / 38.150°N 123.383°W / 38.150; -123.383 (Tomales Bay ) 28.5 km2 (11.0 sq mi) 30 September 2002 Upper Mississippi River Floodplain Wetlands Minnesota , Wisconsin , Iowa , Illinois 43°3′N 91°10′W / 43.050°N 91.167°W / 43.050; -91.167 (Upper Mississippi River Floodplain Wetlands ) 472.42 sq mi 5 January 2010 Wilma H. Schiermeier Olentangy River Wetland Research Park Ohio 40°1′N 83°1′W / 40.017°N 83.017°W / 40.017; -83.017 (Olentangy River Wetland Research Park ) 0.081 sq mi 18 April 2008