Protein-coding gene in the species Homo sapiens
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene .[ 5] [ 6]
MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[ 7]
MYCL1 has been shown to interact with MAX .[ 8] [ 9]
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EMBO J . 8 (6): 1793–9. doi :10.1002/j.1460-2075.1989.tb03573.x . PMC 401025 PMID 2548855 . Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing" . Mol. Cell. Biol . 8 (1): 186–95. doi :10.1128/mcb.8.1.186 . PMC 363100 PMID 2827002 . De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs" . Mol. Cell. Biol . 8 (10): 4381–8. doi :10.1128/mcb.8.10.4381 . PMC 365511 PMID 3054516 . DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene" . Genes Dev . 1 (10): 1311–1326. doi :10.1101/gad.1.10.1311 PMID 3322939 . Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner" . Proc. Natl. Acad. Sci. U.S.A . 92 (22): 10217–10221. Bibcode :1995PNAS...9210217A . doi :10.1073/pnas.92.22.10217 PMC 40767 PMID 7479755 . FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc" . Oncogene . 18 (15): 2489–2498. doi :10.1038/sj.onc.1202611 PMID 10229200 . Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers" . Jpn. J. Cancer Res . 93 (1): 1–5. doi :10.1111/j.1349-7006.2002.tb01193.x . PMC 5926866 PMID 11802801 . Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. 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(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
