Mirodenafil

Mirodenafil
Legal status
Legal status	US: Unscheduled; not FDA-approved; Rx-only (KR);
Identifiers
	IUPAC name 5-Ethyl-3,5-dihydro-2-[5-([4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl)-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one;
CAS Number	862189-95-5 ;
PubChem CID	12001014;
ChemSpider	10173481 ;
UNII	504G362H0H;
ChEBI	CHEBI:136049;
CompTox Dashboard (EPA)	DTXSID50881265 ;
Chemical and physical data
Formula	C26H37N5O5S
Molar mass	531.67 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCc1cn(CC)c2c1[nH]c(nc2=O)c1c(OCCC)ccc(c1)S(=O)(=O)N1CCN(CC1)CCO;
	InChI InChI=1S/C26H37N5O5S/c1-4-7-19-18-30(6-3)24-23(19)27-25(28-26(24)33)21-17-20(8-9-22(21)36-16-5-2)37(34,35)31-12-10-29(11-13-31)14-15-32/h8-9,17-18,32H,4-7,10-16H2,1-3H3,(H,27,28,33) ; Key:MIJFNYMSCFYZNY-UHFFFAOYSA-N ;
	(what is this?) (verify)

Mirodenafil belongs to the drug class PDE5 inhibitors, which includes avanafil, sildenafil, tadalafil, udenafil, and vardenafil, and is the first-line treatment for erectile dysfunction. Developed by SK Chemicals Life Science, mirodenafil is marketed in Korea under the trade name Mvix, offered both as tablets (50 mg and 100 mg) and as orally dissolving films (50 mg).

Despite several clinical trials having been conducted,^[1]^[2]^[3] mirodenafil has not been approved for use in the United States by the U.S. Food and Drug Administration.

References

^ Paick JS, Ahn TY, Choi HK, Chung WS, Kim JJ, Kim SC, Kim SW, Lee SW, Min KS, Moon KH, Park JK, Park K, Park NC, Suh JK, Yang DY, Jung HG (November 2008). "Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction". The Journal of Sexual Medicine. 5 (11): 2672–80. doi:10.1111/j.1743-6109.2008.00945.x. PMID 18638004.
^ Kim BH, Yi S, Kim J, Lim KS, Kim KP, Lee B, Shin SG, Jang IJ, Yu KS (June 2009). "Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea". Clinical Therapeutics. 31 (6): 1234–43. doi:10.1016/j.clinthera.2009.06.008. PMID 19695390.
^ Shin KH, Kim BH, Kim TE, Kim JW, Yi S, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS (December 2009). "The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study". Clinical Therapeutics. 31 (12): 3009–20. doi:10.1016/j.clinthera.2009.12.012. PMID 20110038.

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

[pmid18638004-1] Paick JS, Ahn TY, Choi HK, Chung WS, Kim JJ, Kim SC, Kim SW, Lee SW, Min KS, Moon KH, Park JK, Park K, Park NC, Suh JK, Yang DY, Jung HG (November 2008). "Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction". The Journal of Sexual Medicine. 5 (11): 2672–80. doi:10.1111/j.1743-6109.2008.00945.x. PMID 18638004.

[pmid19695390-2] Kim BH, Yi S, Kim J, Lim KS, Kim KP, Lee B, Shin SG, Jang IJ, Yu KS (June 2009). "Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea". Clinical Therapeutics. 31 (6): 1234–43. doi:10.1016/j.clinthera.2009.06.008. PMID 19695390.

[pmid20110038-3] Shin KH, Kim BH, Kim TE, Kim JW, Yi S, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS (December 2009). "The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study". Clinical Therapeutics. 31 (12): 3009–20. doi:10.1016/j.clinthera.2009.12.012. PMID 20110038.

[1]

[2]

[3]

v t e Sexual dysfunction pharmacotherapies
Dopamine agonists	Apomorphine Cabergoline Lisuride Pergolide Piribedil Pramipexole Quinagolide Ropinirole Rotigotine Terguride
Melanocortin agonists	Bremelanotide Melanotan II PL-6983
PDE5 inhibitors	Acetildenafil Aildenafil Avanafil Icariin Lodenafil Mirodenafil Nitrosoprodenafil Sildenafil Sulfoaildenafil Tadalafil Udenafil Vardenafil
Sex steroids	Androgens (e.g., testosterone, methyltestosterone, other anabolic steroids) Estrogens (e.g., estradiol, ethinylestradiol, conjugated equine estrogens (Premarin)) Progestogens (e.g., progesterone, progestins) Mixed (e.g., tibolone)
Others	Afrodor (acecarbromal, quebracho, vitamin E) Alkyl nitrites Alprostadil Amantadine Bupropion Buspirone Cyproheptadine Dapoxetine Flibanserin Mirtazapine Moxisylyte Oxytocin Papaverine Phentolamine Psychostimulants (e.g., amphetamines, cocaine, methylphenidate) Rauwolscine (Rauvolfia) Trazodone Yohimbine (Yohimbe)
See also: Drugs for erectile dysfunction and premature ejaculation

v t e Phosphodiesterase inhibitors
PDE1	MMPX SCH-51866 Vinpocetine
PDE2	BAY 60-7550 Carbazeran EHNA Oxindole PDP
PDE3	Adibendan Amrinone (inamrinone) Anagrelide Benafentrine Bucladesine Carbazeran Cilostamide Cilostazol Enoximone Ensifentrine Imazodan KMUP-1 Meribendan Milrinone Olprinone Parogrelil Pimobendan Pumafentrine Quazinone RPL-554 Siguazodan Trequinsin Vesnarinone Zardaverine
PDE4	Apremilast Arofylline Atizoram Benafentrine Catramilast CC-1088 CDP-840 CGH-2466 Cilomilast Cipamfylline Crisaborole Denbutylline Difamilast Drotaverine Ensifentrine Etazolate Filaminast Glaucine HT-0712 ICI-63197 Indimilast Irsogladine Lavamilast Lirimilast Lotamilast Luteolin Mesembrenone Mesembrine Mesopram Oglemilast Piclamilast Pumafentrine Revamilast Ro 20-1724 Roflumilast Rolipram Ronomilast RPL-554 RS-25344 Tetomilast Tofimilast YM-976 Zardaverine
PDE5	Acetildenafil Aildenafil Avanafil Beminafil Benzamidenafil Dasantafil Icariin Gisadenafil Homosildenafil Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Norcarbodenafil SCH-51866 Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil
PDE7	BRL-50481
PDE9	BAY 73-6691 PF-04447943 Paraxanthine
PDE10	Balipodect Mardepodect MK-8189 Papaverine TC-E 5005 Tofisopam
PDE11	BC11-38
Non-selective	Aminophylline Caffeine Choline theophyllinate CPX Dipyridamole Doxofylline Enprofylline Ibudilast IBMX Luteolin Pentoxifylline Propentofylline Theobromine Theophylline Zaprinast
Unsorted	Diazepam Diprophylline DPCPX Furafylline Lisofylline MDL-12330A Moxaverine Oxagrelate Pentifylline Proxyphylline Quercetin Satigrel Tolafentrine Trapidil
See also: Receptor/signaling modulators

Legal status

Legal status	US: Unscheduled; not FDA-approved Rx-only (KR)
Identifiers
IUPAC name 5-Ethyl-3,5-dihydro-2-[5-([4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl)-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one
CAS Number	862189-95-5^Y
PubChem CID	12001014
ChemSpider	10173481^N
UNII	504G362H0H
ChEBI	CHEBI:136049
CompTox Dashboard (EPA)	DTXSID50881265
Chemical and physical data
Formula	C₂₆H₃₇N₅O₅S
Molar mass	531.67 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCc1cn(CC)c2c1[nH]c(nc2=O)c1c(OCCC)ccc(c1)S(=O)(=O)N1CCN(CC1)CCO
InChI InChI=1S/C26H37N5O5S/c1-4-7-19-18-30(6-3)24-23(19)27-25(28-26(24)33)21-17-20(8-9-22(21)36-16-5-2)37(34,35)31-12-10-29(11-13-31)14-15-32/h8-9,17-18,32H,4-7,10-16H2,1-3H3,(H,27,28,33)^N Key:MIJFNYMSCFYZNY-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Mirodenafil

References

€4.95