Motile sperm domain containing 2

MOSPD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WIC
Identifiers
Aliases	MOSPD2, Motile sperm domain containing 2
External IDs	MGI: 1924013; HomoloGene: 22125; GeneCards: MOSPD2; OMA:MOSPD2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	14,922,327 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	163,763,371 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; corpus callosum; ; inferior ganglion of vagus nerve; ; monocyte; ; C1 segment; ; subthalamic nucleus; ; visceral pleura; ; blood; ; decidua; ; pons;
	Top expressed in
	parotid gland; ; Epithelium of choroid plexus; ; carotid body; ; ciliary body; ; sciatic nerve; ; iris; ; left lung lobe; ; conjunctival fornix; ; seminal vesicula; ; calvaria;
	More reference expression data
	n/a
Orthologs
	158747
	76763
	ENSG00000130150
	ENSMUSG00000061778
	Q8NHP6
	Q9CWP6
	NM_001177475; NM_152581; NM_001330241
	NM_001290523; NM_001290524; NM_029730
	NP_001170946; NP_001317170; NP_689794
	NP_001277452; NP_001277453; NP_084006
	Wikidata
View/Edit Human	View/Edit Mouse

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene.^[5] It is an endoplasmic reticulum–resident protein involved in membrane contact site formation.^[6] Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Motile sperm domain containing 2".
^ Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F (June 2018). "Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites". EMBO Reports. 19 (7): e45453. doi:10.15252/embr.201745453. PMC 6030701. PMID 29858488.

PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Motile sperm domain-containing protein 2

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