POLE2

POLE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V6Z
Identifiers
Aliases	POLE2, DPE2, polymerase (DNA) epsilon 2, accessory subunit, DNA polymerase epsilon 2, accessory subunit
External IDs	OMIM: 602670; MGI: 1197514; HomoloGene: 2015; GeneCards: POLE2; OMA:POLE2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	49,688,422 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,274,969 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; ventricular zone; ; secondary oocyte; ; mucosa of transverse colon; ; rectum; ; ganglionic eminence; ; right uterine tube; ; mucosa of esophagus; ; ectocervix;
	Top expressed in
	tongue muscle; ; choroidal fissure; ; zygote; ; tail of embryo; ; spermatid; ; genital tubercle; ; blastocyst; ; embryo; ; morula; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; protein binding; DNA-directed DNA polymerase activity;
Cellular component	intracellular membrane-bounded organelle; nucleus; nucleoplasm; nuclear body; epsilon DNA polymerase complex;
Biological process	DNA repair; error-prone translesion synthesis; DNA replication; DNA-dependent DNA replication; G1/S transition of mitotic cell cycle; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	5427
	18974
	ENSG00000100479
	ENSMUSG00000020974
	P56282
	O54956
	NM_001197330; NM_001197331; NM_002692; NM_001348384; NM_001348385
	NM_011133
	NP_001184259; NP_001184260; NP_002683; NP_001335313; NP_001335314
	NP_035263
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.^[5]^[6]^[7]

Interactions

POLE2 has been shown to interact with SAP18.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100479 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020974 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem. 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.
^ Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res. 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964.
^ "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".
^ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase epsilon subunit 2 (POLE2)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100479 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020974 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405441-5] Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem. 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.

[pmid9443964-6] Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res. 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964.

[entrez-7] "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".

[pmid11872158-8] Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

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POLE2

Interactions

References

Further reading

External links

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